Carbamazapine for Inherited Erythromelalgia Patients With NaV1.7 Mutations
| Status: | Enrolling by invitation |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/21/2016 |
| Start Date: | April 2014 |
| End Date: | June 2016 |
Pilot Study on the Response of Inherited Erythromelalgia Patients With NaV1.7 Mutations to Carbamazepine: Clinical Imaging Study
This research study is designed to investigate brain response using fMRI scan, and
behavioral responses, to treatment with the drug carbamazepine (CBZ) in patients with the
painful sodium channelopathy inherited Erythromelalgia (IEM). This study is designed to
identify the central nervous system (CNS) regions that are activated during ongoing or
evoked pain attacks, and the altered CNS response to CBZ treatment. This will advance our
understanding of how IEM affects the brain. We also hope to validate a pharmacogenic
approach to the study of IEM by use of an FDA approved drug. We hope, but cannot be sure,
that subjects will directly benefit from this study.
behavioral responses, to treatment with the drug carbamazepine (CBZ) in patients with the
painful sodium channelopathy inherited Erythromelalgia (IEM). This study is designed to
identify the central nervous system (CNS) regions that are activated during ongoing or
evoked pain attacks, and the altered CNS response to CBZ treatment. This will advance our
understanding of how IEM affects the brain. We also hope to validate a pharmacogenic
approach to the study of IEM by use of an FDA approved drug. We hope, but cannot be sure,
that subjects will directly benefit from this study.
Inclusion Criteria:
- diagnosis/symptoms of EM
- specific NaV1.7 sodium channel mutations (including S241T)
Exclusion Criteria:
- patients with no identified NaV1.7 mutation
We found this trial at
2
sites
Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
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VA Connecticut Healthcare System VA Connecticut encompasses an inpatient facility and Ambulatory Care Center in...
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