Collection of Retrospective (Archival) Samples and Prospective Collection of Surplus Tissue and Blood Samples

This study will enroll specimens from subjects diagnosed with various cancers and who have
either:

1. RETROSPEFCTIVE / ARCHIVAL SAMPLES already undergone surgical resection of their tumor
and have one or more formalin fixed and paraffin embedded (FFPE) blocks on file within
the local (or affiliated) pathology archive (replicate blocks from same tumor) or blocks
no longer required to be maintained on file - discard blocks, or

2. PROSPECTIVE SAMPLES are scheduled to undergo surgical treatment and who prior to
scheduled surgery, provide informed consent and donate a 10-20 ml blood sample. After
surgery, surplus tissues (including tumor and adjacent normal tissues) not required for
diagnosis will be collected.

Subject clinical information will be collected, including basic demographic information,
medical history, current cancer history and treatment. A final pathology report will be
obtained for each subject's surgical specimen. In some instances, and based on the cancer
indications required, longitudinal data may also be collected at a frequency of every 6
months to once per year. Longitudinal data will include information on study subject survival
and disease recurrence.