Skin Safety Study to Evaluate the Sensitizing Potential in Healthy Volunteers

During the Induction Phase of the study, the study drugs and controls will be applied 9
times for 21 days on the infrascapular area of the back under occlusive patch conditions.

Following induction, subjects will have a 10 to 14-day Rest phase, after which they will
enter the challenge Phase, which consists of one 48-hour patch application (occlusive) to a
naïve site on the opposite side of the back.

Inclusion Criteria:

- Health male or female subjects are age 18 years or older

- Signed and dated Informed Consent Form obtained prior to any study related activities

- Subjects are free of any systemic or dermatologic disorder

- For female, females of non childbearing potential or who agree to use a highly
effective method of birth control during the study and have a negative urine
pregnancy test

- Subjects must be able to communicate with the investigator and understand and comply
with the requirement of the study and visit schedule

Exclusion Criteria:

- Have any visible skin disease at the application site which will interfere with the
evaluation of the test site reaction

- Have damaged skin in or around the test sites

- Have a history of sensitivity to adhesive tape

- Have a known sensitivity to constituents present in the material being evaluated

- Have a history of, or are currently being treated for skin cancer

- Have used any study drug and/or participate in any clinical study within 60 days
prior to randomization

- To engage in any type of strenuous exercise

- Are pregnant, breastfeeding, or of childbearing potential and who wish to become
pregnant during the study

- Are deemed to be ineligible by the investigator