Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID)-2.0
| Status: | Active, not recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 30 - 55 |
| Updated: | 8/11/2018 |
| Start Date: | November 11, 2014 |
| End Date: | July 1, 2030 |
The Minority Health Genomics and Translational Research BIo-Repository Database (MH-GRID)-2.0
Background:
- High blood pressure is a common problem. It can cause heart attacks, strokes, and kidney
failure. It affects African Americans more than other racial groups. Data were collected from
over a thousand African Americans across the country. The data were put into a database
(MH-GRID). The data were about genes, diet, sleep, body mass index. They also cover stress
and access to healthy foods and parks. Researchers at NIH will study these data in new ways.
They want to learn more about the connection between African Americans and high blood
pressure.
Objective:
- To study MH-GRID data to find the causes of severe high blood pressure and other
cardio-metabolic problems in people of African ancestry.
Eligibility:
- African Americans age 30 55 with severe high blood pressure were used in the MH-GRID study.
No new participants will be enrolled in this study.
Design:
- Researchers will examine data from the MH-GRID study.
- High blood pressure is a common problem. It can cause heart attacks, strokes, and kidney
failure. It affects African Americans more than other racial groups. Data were collected from
over a thousand African Americans across the country. The data were put into a database
(MH-GRID). The data were about genes, diet, sleep, body mass index. They also cover stress
and access to healthy foods and parks. Researchers at NIH will study these data in new ways.
They want to learn more about the connection between African Americans and high blood
pressure.
Objective:
- To study MH-GRID data to find the causes of severe high blood pressure and other
cardio-metabolic problems in people of African ancestry.
Eligibility:
- African Americans age 30 55 with severe high blood pressure were used in the MH-GRID study.
No new participants will be enrolled in this study.
Design:
- Researchers will examine data from the MH-GRID study.
The etiology of racial/ethnic differences in health involves dynamic interactions between
genetic, behavioral and social-environmental determinants. Despite this, the field lacks
robust
datasets that integrate these determinants with clinical assessments in minority patient
cohorts. The Minority Health Genomics and Translational Research Bio-repository Database
(MHGRID) Network infrastructure facilitated the collection of biospecimens and related
multidimensional data elements within a consortium of minority-serving clinics. This
initiative expands the diversity of ancestral groups in national genomic medicine datasets
and promises to accelerate the translation of personalized medicine into minority
communities. The MH-GRID project was initiated by Dr. Gibbons (founding PI) prior to becoming
an NIH investigator. The MH-GRID project has completed its participant recruitment
activities, closed out its NIH funding and now represents an existing dataset and
biorepository that is being transferred to NHGRI for ongoing secondary analyses. A variety of
investigations will be conducted on this existing dataset. The primary outcome variables
include severe hypertension and hypertension induced kidney damage. Secondary outcome
variables include obesity, coronary heart disease and metabolic disease syndrome. Intervening
variables include genetics, behavioral (i.e. sleep quality, health literacy, smoking, diet,
body mass index), ancestry, social (i.e. socioeconomic status, racial discrimination, stress,
social depreivation), biological (i.e. insulin resistance, cholesterol, inflammatory
markers), and environmental (i.e. neighborhood, access to healthy foods, parks).
genetic, behavioral and social-environmental determinants. Despite this, the field lacks
robust
datasets that integrate these determinants with clinical assessments in minority patient
cohorts. The Minority Health Genomics and Translational Research Bio-repository Database
(MHGRID) Network infrastructure facilitated the collection of biospecimens and related
multidimensional data elements within a consortium of minority-serving clinics. This
initiative expands the diversity of ancestral groups in national genomic medicine datasets
and promises to accelerate the translation of personalized medicine into minority
communities. The MH-GRID project was initiated by Dr. Gibbons (founding PI) prior to becoming
an NIH investigator. The MH-GRID project has completed its participant recruitment
activities, closed out its NIH funding and now represents an existing dataset and
biorepository that is being transferred to NHGRI for ongoing secondary analyses. A variety of
investigations will be conducted on this existing dataset. The primary outcome variables
include severe hypertension and hypertension induced kidney damage. Secondary outcome
variables include obesity, coronary heart disease and metabolic disease syndrome. Intervening
variables include genetics, behavioral (i.e. sleep quality, health literacy, smoking, diet,
body mass index), ancestry, social (i.e. socioeconomic status, racial discrimination, stress,
social depreivation), biological (i.e. insulin resistance, cholesterol, inflammatory
markers), and environmental (i.e. neighborhood, access to healthy foods, parks).
- INCLUSION CRITERIA:
- The MH-GRID Project s inclusion criteria included AA age 30-55 years
- Severe controlled HTN or severe resistant HTN.
EXCLUSION CRITERIA:
- Exclusion criteria involved patients with secondary forms of HTN, primary forms of
kidney disease or major co-morbidities (e.g. diabetes, heart failure, end-stage renal
failure, HIV, and liver disease).
- Children <18 were not enrolled in the protocol.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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