Imaging and Understanding BOS in Lung Transplantation
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Bronchitis, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 1 - 25 |
| Updated: | 4/21/2016 |
| Start Date: | December 2014 |
| End Date: | December 2027 |
This study is a prospective, non-randomized, longitudinal, observational study that will
recruit about 5 lung transplant patients per year for 3 years.
recruit about 5 lung transplant patients per year for 3 years.
This study is a prospective, non-randomized, longitudinal, observational study that will
recruit about 5 lung transplant patients per year for 3 years. We will follow these patients
at 6 months and 1 year with Hyperpolarized Helium-3 Magnetic Resonance Imaging and image
guided bronchial biopsies to detect early BOS and to better understand BO disease
progression. The biopsies will provide future research for rapid determination of cellular
and molecular mechanisms that lead to BOS and to facilitate identification and validation of
translatable pharmaceutical targets.
recruit about 5 lung transplant patients per year for 3 years. We will follow these patients
at 6 months and 1 year with Hyperpolarized Helium-3 Magnetic Resonance Imaging and image
guided bronchial biopsies to detect early BOS and to better understand BO disease
progression. The biopsies will provide future research for rapid determination of cellular
and molecular mechanisms that lead to BOS and to facilitate identification and validation of
translatable pharmaceutical targets.
Inclusion Criteria:
- Lung Transplantation within the last 10 years or being assessed for possible lung
transplantation.
- Male or female
- 0 to 25 years of age.
Exclusion Criteria:
- Standard MRI exclusion criteria as set forth by the CCHMC Division of Radiology
- Inability to perform 10 second breath hold for 3He MRI scan
- Bleeding disorders
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