Intra-Articular Dexamethasone to Prevent Post-Traumatic Osteoarthritis: A Pilot Study



Status:Active, not recruiting
Conditions:Arthritis, Osteoarthritis (OA)
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - 65
Updated:3/27/2019
Start Date:December 2014
End Date:December 2021

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria
The primary aim of the study is to see if a single wrist injection (intra-articular) of
dexamethasone at the time of treatment will reduce the incidence of early-onset of post
traumatic osteoarthritis.

Our hypothesis is that the intra-articular administration of dexamethasone soon after joint
injury will prevent the subsequent development of PTOA, and restore normal joint homeostasis.
We plan to generate the data needed to test this hypothesis in a Phase 0 (pilot) clinical
trial using patients who have suffered distal radius fractures.

Inclusion Criteria:

1. Unstable distal radius fracture

2. Fracture type AO B1, B2, B3, C1, C2 or C3.

3. 18-65 years old

4. Understand and read English

5. Community dwelling (not in assisted living or NH)

Exclusion criteria:

1. Open or bilateral DRF

2. Associated upper extremity carpal fracture or carpal ligament injuries requiring
casting or surgical repair at the time of DRF fixation.

3. Greater than 2 weeks post injury

4. Neurologic disorders affecting the hand, wrist or arm.

5. History of permanent dementia, Alzheimer's or other neurologic dx

6. Substance abuse

7. Pathologic fractures

8. Known pregnancy

9. Radiocarpal joint arthritis
We found this trial at
1
site
Mayo Clinic Rochester
200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
?
mi
from
Rochester, MN
Click here to add this to my saved trials