Evaluate Cardiac Function Using Cardiac MRI and Dosimetric Correlation
| Status: | Withdrawn |
|---|---|
| Conditions: | Breast Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - 95 |
| Updated: | 4/21/2016 |
| Start Date: | March 2012 |
| End Date: | December 2014 |
Pilot Study to Evaluate Cardiac Function Using Cardiac MRI and Dosimetric Correlation in Women Treated for Node Positive Breast Cancer With Three- Dimensional Conformal Radiation Therapy (3DCRT)
The association between radiation exposure and cardiac disease is well recognized, it is not
fully understood if there exists an optimal or "safe" radiation dose-volume relationship.
fully understood if there exists an optimal or "safe" radiation dose-volume relationship.
Identification of "safe" dose volume constraints (DVC) for the heart from breast cancer
radiotherapy would permit maximal oncologic benefit from radiation, identifying which
patients require more complicated and resource consumptive radiation methods such as
respiratory-gating or intensity modulated radiotherapy (IMRT) and establish patients who
need targeted follow-up for their long term cardiac risk. Two recent technical developments
now make it conceivable to identify the dose-volume relationship between heart dose and
subsequent cardiac event risk: 1. CT based three dimensional conformal radiation delivery
methods (3DCRT) where the precise radiation dose to any given heart volume is known, and 2.
Cardiac MRI (CMR) that is more sensitive to prior methods of cardiac evaluation (e.g. SPECT)
for detecting and measuring cardiac injury.
An MRI, subject health questionnaire, clinical and dosimetric data will be included in the
analysis.
radiotherapy would permit maximal oncologic benefit from radiation, identifying which
patients require more complicated and resource consumptive radiation methods such as
respiratory-gating or intensity modulated radiotherapy (IMRT) and establish patients who
need targeted follow-up for their long term cardiac risk. Two recent technical developments
now make it conceivable to identify the dose-volume relationship between heart dose and
subsequent cardiac event risk: 1. CT based three dimensional conformal radiation delivery
methods (3DCRT) where the precise radiation dose to any given heart volume is known, and 2.
Cardiac MRI (CMR) that is more sensitive to prior methods of cardiac evaluation (e.g. SPECT)
for detecting and measuring cardiac injury.
An MRI, subject health questionnaire, clinical and dosimetric data will be included in the
analysis.
Inclusion Criteria:
- Women with node positive breast cancer treated with surgery, anthracycline-based
chemotherapy, and regional nodal irradiation between 2000-2007.
Exclusion Criteria:
- Women who have not received anthracycline-based chemotherapy, and regional nodal
irradiation between 2000-2007.
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