Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers.
| Status: | Completed |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/26/2018 |
| Start Date: | September 2014 |
| End Date: | April 2016 |
Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers
The purpose of the study is to compare two modalities of local anesthetic administration
prior to the placement of cosmetic facial injectable fillers. Both short and long term pain
perceptions for the facial filler procedure will be compared in patients receiving 4%
Topicaine gel on half their face, and 20% benzocaine gel prior to 2% lidocaine 1:100k
epinephrine nerve block injections on the other half of their face. The objective is to
quantify the subjective pain experienced by these two modalities of local anesthetic during
the procedure of Juvederm XC filler injections.
prior to the placement of cosmetic facial injectable fillers. Both short and long term pain
perceptions for the facial filler procedure will be compared in patients receiving 4%
Topicaine gel on half their face, and 20% benzocaine gel prior to 2% lidocaine 1:100k
epinephrine nerve block injections on the other half of their face. The objective is to
quantify the subjective pain experienced by these two modalities of local anesthetic during
the procedure of Juvederm XC filler injections.
The purpose of this study is to determine if local anesthesia injections will provide more
profound analgesia than topical anesthesia during facial cosmetic filler injections. The
study is a single group study design. The attending surgeon or residents will perform the
procedure. Each procedure will start with a randomized coin flip to determine which side of
the face will be anesthetized with local anesthesia or topical anesthesia. The head side of
the coin will coincide with local anesthesia on the patient's right side. The tail of the
coin will designate the patient's left side for local anesthetic injections.
To evaluate whether the additional anesthesia of a nerve block brings more pain relief than
the initial pain of receiving a nerve block, the pain value will be collected from each nerve
block administered. Procedural injection pain data will be collected from the nerve blocked
facial half and from the topical anesthetic facial half to provide a comparison of anesthesia
during the procedure. The primary outcome will be the collection of "overall" pain data from
each side of the face 5-10 minutes after the procedure. Facial anesthesia preference data
will also be collected at one week post treatment to determine overall pain perceptions from
each method of facial anesthesia.
profound analgesia than topical anesthesia during facial cosmetic filler injections. The
study is a single group study design. The attending surgeon or residents will perform the
procedure. Each procedure will start with a randomized coin flip to determine which side of
the face will be anesthetized with local anesthesia or topical anesthesia. The head side of
the coin will coincide with local anesthesia on the patient's right side. The tail of the
coin will designate the patient's left side for local anesthetic injections.
To evaluate whether the additional anesthesia of a nerve block brings more pain relief than
the initial pain of receiving a nerve block, the pain value will be collected from each nerve
block administered. Procedural injection pain data will be collected from the nerve blocked
facial half and from the topical anesthetic facial half to provide a comparison of anesthesia
during the procedure. The primary outcome will be the collection of "overall" pain data from
each side of the face 5-10 minutes after the procedure. Facial anesthesia preference data
will also be collected at one week post treatment to determine overall pain perceptions from
each method of facial anesthesia.
Inclusion Criteria:
- Age ≥ 18
- Patients with deepened labiomental folds or decreased lip volume and architecture who
are scheduled to receive Juvederm XC injections in DGMC Oral & Maxillofacial Surgery
clinic.
Exclusion Criteria:
- Pregnant or nursing
- History of any type of neuralgia or paresthesia, or paresis
- Allergy or contraindication to lidocaine or hyaluronic acid
- Use of hyaluronic acid in last 6 months
- Previous reaction to Juvederm or other hyaluronic acid based fillers
- Have an active inflammatory or infectious process at the injection site.
- Use of monoamine oxidase (MAO) inhibitors or tricyclic antidepressants
- Severe coronary artery disease
- Diagnosis of any cardiac dysrhythmia with an ECG finding other than normal sinus
rhythm
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