Oral Alkali Production and Caries Prevention in Children (Longitudinal)
| Status: | Completed |
|---|---|
| Conditions: | Other Indications, Dental |
| Therapuetic Areas: | Dental / Maxillofacial Surgery, Other |
| Healthy: | No |
| Age Range: | 2 - 7 |
| Updated: | 11/14/2018 |
| Start Date: | October 2012 |
| End Date: | August 27, 2015 |
Oral Alkali Production and Caries Prevention in Children (Longitudinal Component)
The fact that dental caries remains a major public health problem mandates that oral-health
researchers explore new strategies for assessment of caries risk, as well as for caries
prevention and management. Dental caries occurs when acids produced by bacterial glycolysis
of dietary carbohydrates causes demineralization of the tooth enamel. A major focus of caries
research has been on identifying and characterizing acid-generating bacteria and the
mechanisms of acid resistance. The purpose of this study is to investigate over time the
relationship between alkali production and caries.
researchers explore new strategies for assessment of caries risk, as well as for caries
prevention and management. Dental caries occurs when acids produced by bacterial glycolysis
of dietary carbohydrates causes demineralization of the tooth enamel. A major focus of caries
research has been on identifying and characterizing acid-generating bacteria and the
mechanisms of acid resistance. The purpose of this study is to investigate over time the
relationship between alkali production and caries.
This study will require a total of 6 study visits over a 2 to 3 year period. The first study
visit will last about one hour. At this study visit, parent-administered questionnaires will
be used to collect information on the following: (a) the participant's demographic background
(age, gender, and race), (b) socio-economic status (parents' income and housing condition),
(c) participant's oral health practice (feeding histories, diet habits, oral hygiene
measures, and dental attendance), and (d) systemic diseases. During the study visit, the
participant's complete medical and dental history will be obtained and reviewed, and a dental
exam will be performed in order to determine participants' caries status, and intraoral
pictures may be taken of participants' teeth. At this visit and remaining visits participants
will not be allowed to brush or clean teeth using any type of oral hygiene procedures for 8
hours prior to the visit. Saliva and plaque (the solf white-yellowish material on the tooth
surface) will be collected at each visit. The Investigator will use a small probe to measure
the pH of the dental plaque that builds up on the teeth. The participant will be asked to dip
one finger into a glass containing a buffer solution and the probe will be placed on the
teeth from which plaque will be taken. Plaque samples will be collected by gently scrapping
the tooth using a sterile instrument. If the participant does not have enough plaque samples,
they will be asked to return on the following day.
visit will last about one hour. At this study visit, parent-administered questionnaires will
be used to collect information on the following: (a) the participant's demographic background
(age, gender, and race), (b) socio-economic status (parents' income and housing condition),
(c) participant's oral health practice (feeding histories, diet habits, oral hygiene
measures, and dental attendance), and (d) systemic diseases. During the study visit, the
participant's complete medical and dental history will be obtained and reviewed, and a dental
exam will be performed in order to determine participants' caries status, and intraoral
pictures may be taken of participants' teeth. At this visit and remaining visits participants
will not be allowed to brush or clean teeth using any type of oral hygiene procedures for 8
hours prior to the visit. Saliva and plaque (the solf white-yellowish material on the tooth
surface) will be collected at each visit. The Investigator will use a small probe to measure
the pH of the dental plaque that builds up on the teeth. The participant will be asked to dip
one finger into a glass containing a buffer solution and the probe will be placed on the
teeth from which plaque will be taken. Plaque samples will be collected by gently scrapping
the tooth using a sterile instrument. If the participant does not have enough plaque samples,
they will be asked to return on the following day.
Inclusion Criteria:
- Age 2 to 7 years
Exclusion Criteria:
- Treated with antibiotics within the past 3 months
- taking any medication at the time of the study
- uses orthodontic appliance, and
- has performed oral hygiene procedures in the past 8 hour prior to the collection
appointment.
We found this trial at
1
site
Click here to add this to my saved trials
