Project Get Fit With MS: Guidelines for Exercise Training and Fitness Outcomes in MS
| Status: | Completed |
|---|---|
| Conditions: | Neurology, Multiple Sclerosis |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 54 |
| Updated: | 4/21/2016 |
| Start Date: | October 2013 |
| End Date: | December 2014 |
Project GET FIT With MS: Guidelines for Exercise Training and Fitness Outcomes in MS
The purpose of this study is to test different types of exercise training for people with
multiple sclerosis (MS). The exercise program is based on physical activity guidelines that
have been developed specifically for people with MS. The investigators believe these
guidelines will be effective for improving physical fitness and function in persons with
mild-to-moderate MS.
multiple sclerosis (MS). The exercise program is based on physical activity guidelines that
have been developed specifically for people with MS. The investigators believe these
guidelines will be effective for improving physical fitness and function in persons with
mild-to-moderate MS.
Most adults with multiple sclerosis (MS) are physically inactive. One approach to address
physical inactivity in this population has involved the provision of physical activity
guidelines. Such physical activity guidelines are an important tool for exercise
prescription, promotion, and monitoring, and recommend that people with MS "participate in
at least 30 minutes of moderate intensity aerobic activity 2 times per week and strength
training exercises for major muscle groups 2 times per week." The guidelines were developed
from a systematic literature review and have yet to be tested for efficacy in improving
fitness or other outcomes. This study will test that efficacy of aerobic and resistance
training alone and in combination (based on the MS physical activity guidelines) for
improving physical fitness and other outcomes (e.g., walking, thinking, MS symptoms) in
persons with MS who have mild-to-moderate disability. Such an examination will be important
to confirm the efficacy of the exercise prescription for people with MS and health-care
providers. The investigators will further perform an exploratory analysis of blood
biomarkers and eye imaging parameters to examine some of the mechanisms of exercise training
effects in persons with MS.
physical inactivity in this population has involved the provision of physical activity
guidelines. Such physical activity guidelines are an important tool for exercise
prescription, promotion, and monitoring, and recommend that people with MS "participate in
at least 30 minutes of moderate intensity aerobic activity 2 times per week and strength
training exercises for major muscle groups 2 times per week." The guidelines were developed
from a systematic literature review and have yet to be tested for efficacy in improving
fitness or other outcomes. This study will test that efficacy of aerobic and resistance
training alone and in combination (based on the MS physical activity guidelines) for
improving physical fitness and other outcomes (e.g., walking, thinking, MS symptoms) in
persons with MS who have mild-to-moderate disability. Such an examination will be important
to confirm the efficacy of the exercise prescription for people with MS and health-care
providers. The investigators will further perform an exploratory analysis of blood
biomarkers and eye imaging parameters to examine some of the mechanisms of exercise training
effects in persons with MS.
Inclusion Criteria:
- a definite diagnosis of MS
- self-reported Expanded Disability Status Scale (EDSS) score < 6.0 or Patient
Determined Disability Steps (PDDS) scale score ≤ 3.0
- relapse free in past 30 days
- willing and able to visit the University of Illinois at Urbana-Champaign for on seven
occasions (two testing visits; five training visits) and participate in a 6-month
home-based exercise program
- non-exerciser
- asymptomatic and physician approval for undertaking exercise testing and training
Exclusion Criteria:
- currently pregnant
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