Genetics of Wilms' Tumor and/or the Associated Conditions of Aniridia, Hemihypertrophy, and Genitourinary Anomalies
| Status: | Recruiting |
|---|---|
| Conditions: | Cancer, Ocular, Women's Studies, Urology |
| Therapuetic Areas: | Nephrology / Urology, Oncology, Ophthalmology, Reproductive |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 1/16/2019 |
| Start Date: | December 1, 1980 |
| End Date: | December 2019 |
| Contact: | Louise C. Strong, MD |
| Phone: | 713-792-7555 |
The goal of this clinical research study is to collect information and blood samples to try
to learn why some people develop cancers and tumors, why some families have more cancers than
others, and whether certain genes or regions of DNA (the genetic material of cells) affect a
person's risk of getting cancer.
This is an investigational study.
Up to 1500 patients and family members will take part in this study. All will be enrolled at
MD Anderson.
to learn why some people develop cancers and tumors, why some families have more cancers than
others, and whether certain genes or regions of DNA (the genetic material of cells) affect a
person's risk of getting cancer.
This is an investigational study.
Up to 1500 patients and family members will take part in this study. All will be enrolled at
MD Anderson.
If you choose to take part in this study, blood (about 10 teaspoons) will be drawn for
genetic testing. The blood may be drawn more than 1 time, depending on how much blood is
drawn at the first visit, and if you are available for more blood draws. If this is the case,
your doctor will discuss any extra blood draws with you.
For small children (less than 5 years old), about 2 teaspoons will be drawn. Children who are
5 years old or older will not have more than 3 teaspoons drawn.
You will complete a questionnaire about your medical history and family medical history. The
questionnaire should take about 1 hour to complete. The study staff will also review your
medical records.
You will be asked to allow the study staff to collect any of your tissue (whether healthy or
cancerous) that is leftover from surgeries performed as part of your standard care. This may
be from any past or future surgeries or any tissue being stored at MD Anderson or elsewhere.
No new surgeries or biopsies will be performed for this study.
Before your information, tissue samples, and/or bodily fluids can be used for research, the
people doing the research must get specific approval from the Institutional Review Board
(IRB) of MD Anderson. The IRB is a committee made up of doctors, researchers, and members of
the community. The IRB is responsible for protecting the participants involved in research
studies and making sure all research is done in a safe and ethical manner. All research done
at MD Anderson, including research involving your information, tissue samples, and/or bodily
fluids, must first be approved by the IRB.
You may be contacted either by phone or mail 1 time a year, so that the study staff can
update your medical history and information. If contacted by phone, this call should last
about 30 minutes.
genetic testing. The blood may be drawn more than 1 time, depending on how much blood is
drawn at the first visit, and if you are available for more blood draws. If this is the case,
your doctor will discuss any extra blood draws with you.
For small children (less than 5 years old), about 2 teaspoons will be drawn. Children who are
5 years old or older will not have more than 3 teaspoons drawn.
You will complete a questionnaire about your medical history and family medical history. The
questionnaire should take about 1 hour to complete. The study staff will also review your
medical records.
You will be asked to allow the study staff to collect any of your tissue (whether healthy or
cancerous) that is leftover from surgeries performed as part of your standard care. This may
be from any past or future surgeries or any tissue being stored at MD Anderson or elsewhere.
No new surgeries or biopsies will be performed for this study.
Before your information, tissue samples, and/or bodily fluids can be used for research, the
people doing the research must get specific approval from the Institutional Review Board
(IRB) of MD Anderson. The IRB is a committee made up of doctors, researchers, and members of
the community. The IRB is responsible for protecting the participants involved in research
studies and making sure all research is done in a safe and ethical manner. All research done
at MD Anderson, including research involving your information, tissue samples, and/or bodily
fluids, must first be approved by the IRB.
You may be contacted either by phone or mail 1 time a year, so that the study staff can
update your medical history and information. If contacted by phone, this call should last
about 30 minutes.
Inclusion Criteria:
1. Patients with familial and sporadic Wilm's tumor, genitourinary anomalies,
Beckwith-Wiedemann hemihypertrophy and/or aniridia, and family members of patients.
Exclusion Criteria:
1. Patients who do not meet inclusion eligibility criteria are excluded.
We found this trial at
1
site
1515 Holcombe Blvd
Houston, Texas 77030
Houston, Texas 77030
713-792-2121
Principal Investigator: Louise C. Strong, MD
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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