Stress Response and Neurodevelopmental Outcome After Cardiac Surgery Utilizing CPB in Children: A Prospective, Double Blinded and Randomized Study
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 9/7/2018 |
| Start Date: | May 2014 |
| End Date: | December 2024 |
The overall goal of this project is to determine the role of anesthetic management in
children undergoing cardiac surgery utilizing CPB in the setting of fast tracking and early
extubation. An ideal anesthetic technique would ensure abolishing or diminishing stress
response as would be evident by the stress markers levels and the level of two cerebral
injury biomarkers (S 100 B and NSE). This should translate to better immediate postoperative
outcome and hopefully improve both the short and the long term neurodevelopmental outcome in
these children. The project is prospective, randomized and blinded study. The first and
second aim of the study should be conducted over 2 year period. Our long term aim will be
concluded when these children reach the school age.
children undergoing cardiac surgery utilizing CPB in the setting of fast tracking and early
extubation. An ideal anesthetic technique would ensure abolishing or diminishing stress
response as would be evident by the stress markers levels and the level of two cerebral
injury biomarkers (S 100 B and NSE). This should translate to better immediate postoperative
outcome and hopefully improve both the short and the long term neurodevelopmental outcome in
these children. The project is prospective, randomized and blinded study. The first and
second aim of the study should be conducted over 2 year period. Our long term aim will be
concluded when these children reach the school age.
Inclusion Criteria:
- Patients with the following diagnosis:
1. ASD
2. VSD
3. AVSD
4. TOF
5. Biventricular repair with left to right shunt.
Exclusion Criteria:
- Patients with the diagnosis of AVSD and pulmonary hypertension
- Patients less than 1 year and require any of the following repairs:
1. HLHS
2. Aortic arch reconstruction
3. Arterial switch
4. TOF with pulmonary atresia
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