Isolated Limb Perfusion With Melphalan in Treating Patients With Stage IIIB-IV Melanoma or Sarcoma

PRIMARY OBJECTIVES:

I. This prospective trial will evaluate total response rate, including complete and partial
response, in patients with unresectable extremity melanoma (or other skin cancer including
but not limited to Merkel cell carcinoma) or soft tissue sarcoma treated with
hyperthermic-isolated limb perfusion (ILP) with melphalan.

SECONDARY OBJECTIVES:

I. To evaluate the technical parameters including achievement of regional hyperthermia,
arterial blood gas (ABG), tourniquet time, and their association with tumor response.

II. To evaluate time to recurrence and progression free survival (PFS) for patients with
advanced extremity melanoma or sarcoma who achieved complete response after treatment with
ILP with melphalan.

III. To evaluate overall survival rate and duration of survival for patients with advanced
melanoma or sarcoma limited to extremity undergoing ILP with melphalan.

IV. To assess quality of life (QOL) score for patients undergoing ILP with melphalan.

OUTLINE:

Patients undergo ILP with melphalan intravenously (IV) over 60 minutes.

After completion of study treatment, patients are followed up every 3 months for 2 years,
every 4 months for 1 year, and then periodically thereafter.

Inclusion Criteria:

- Eastern Cooperative Oncology Group (ECOG) performance status of 0-1

- The patient must have histological-proven primary or recurrent extremity melanoma (or
other skin cancer including but not limited to Merkel cell carcinoma) or sarcoma,
stage IIIB, IIIC, or IV (American Joint Committee on Cancer [AJCC] staging must be
documented in patient's medical record, as determined by computed tomography [CT] of
the chest, abdomen and pelvis, and/or whole body positron emission tomography [PET]
scan, within six weeks prior to administration of study drug)

- Patients with stage IV disease who have high tumor burden and extensive symptomatic
extremity disease

- Patients with stage IIIC disease must either have had regional lymph nodes previously
removed or will have them removed either at the time of regional treatment or soon
thereafter

- Disease to be treated by ILP must be unresectable and distal to the planned site of
tourniquet placement (which for the leg is generally the apex of the femoral
triangle, or for the arm is distal to the deltoid insertion)

- Patient's disease must be bi-dimensionally measurable by caliper or radiological
method as defined in the Response Evaluation Criteria in Solid Tumors (RECIST)
criteria (RECIST updated version 1.1); lesional tissue not necessary for diagnostic
or other clinical purposes may be designated prospectively for research tissue
banking

- Hemoglobin >= 8.0 g/dl

- White blood count (WBC) of >= 2000 m^3

- Absolute neutrophil count (ANC) >= 1,500/mm^3

- Platelet count >= 100,000/mm^3

- Total bilirubin =< 1.5 x upper limit of normal (ULN)

- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x the ULN

- Creatinine =< 1.5 x ULN

- Patient must have a palpable femoral/radial pulse in the affected extremity

- Patients must have a life expectancy of > 6 months

- Patient or the patient's legally acceptable representative must provide a signed and
dated written informed consent prior to registration and any study-related procedures

- Patient or the patient's legally acceptable representative must provide written
authorization to allow the use and disclosure of their protected health information
at any institution subject to United States Health Insurance Portability and
Accountability Act (US HIPAA) regulations; NOTE: This may be obtained in either the
study-specific informed consent or in a separate authorization form and must be
obtained from the patient prior to study registration

Exclusion Criteria:

- Cardiac disease: congestive heart failure > class II New York Heart Association
(NYHA); patients must not have unstable angina (angina symptoms at rest) or new onset
angina (began within the last 3 months) or myocardial infarction within the past 6
months

- Known brain metastasis; patients with neurological symptoms must undergo a CT
scan/magnetic resonance imaging (MRI) of the brain to exclude brain metastasis

- Known human immunodeficiency virus (HIV) infection or chronic hepatitis B or C

- Active clinically serious infection > Common Terminology Criteria for Adverse Events
(CTCAE) grade 2

- Thrombotic or embolic events such as a cerebrovascular accident including transient
ischemic attacks within the past 6 months

- Pulmonary hemorrhage/bleeding event >= CTCAE grade 2 within 4 weeks of ILP/isolated
limb infusion (ILI); any other hemorrhage/bleeding event >= CTCAE grade 3 within 4
weeks ILP/ILI

- Major surgery or significant traumatic injury within 30 days of ILI/ILP

- Evidence or history of bleeding diathesis or coagulopathy

- Antineoplastic therapy, radiotherapy, or any other investigational drug within 30
days prior to first study drug administration

- Patients with symptoms or signs of vascular insufficiency; specifically, patients
with any history of blood clots or lifestyle altering ischemic peripheral vascular
disease will be excluded

- History of allergic reactions and/or hypersensitivity to melphalan

- Psychiatric conditions or diminished capacity that could compromise the giving of
informed consent, or interfere with study compliance

- Pregnant or nursing women are not eligible for this study

- Unable to return at the regular required intervals for reassessment, or study drug
administration

- Patients with known heparin induced thrombocytopenia