Wine Consumption and Glycemic Control
| Status: | Completed |
|---|---|
| Conditions: | Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 21 - 65 |
| Updated: | 10/28/2017 |
| Start Date: | March 2012 |
| End Date: | March 2015 |
Many studies have reported that alcoholic beverage consumption, especially in the form of
wine, reduces the risk of developing type 2 diabetes by as much as 40%. This association
suggests that wine consumption may somehow improve the body's ability to control its blood
glucose concentration. Indeed, it has been reported that when wine is consumed immediately
prior to ingestion of glucose, the release of insulin is enhanced and blood glucose
concentration is lowered. The mechanism of wine's effects on blood glucose concentration is
unknown, but is likely related to its ethanol or antioxidant content. In this study, the
investigators plan to test whether wine or plain ethanol (vodka) ingestion alters the control
of blood glucose in subjects who have diabetes or pre-diabetes.
wine, reduces the risk of developing type 2 diabetes by as much as 40%. This association
suggests that wine consumption may somehow improve the body's ability to control its blood
glucose concentration. Indeed, it has been reported that when wine is consumed immediately
prior to ingestion of glucose, the release of insulin is enhanced and blood glucose
concentration is lowered. The mechanism of wine's effects on blood glucose concentration is
unknown, but is likely related to its ethanol or antioxidant content. In this study, the
investigators plan to test whether wine or plain ethanol (vodka) ingestion alters the control
of blood glucose in subjects who have diabetes or pre-diabetes.
Our central hypothesis is that improvement in glycemic control by acute consumption of wine
is mediated by ethanol. Subjects will have type 2 diabetes, pre-diabetes, and be sedentary
and obese (BMI >30). Subjects' glycemic control will be assessed by an oral glucose tolerance
test (OGTT) at three different time points. One OGTT will occur shortly after consumption of
red wine, the second after consumption of vodka containing the identical amount of ethanol as
the wine treatment, and the third OGTT will occur shortly after consumption of an equal
volume of water. The three OGTTs will be administered in random order.
is mediated by ethanol. Subjects will have type 2 diabetes, pre-diabetes, and be sedentary
and obese (BMI >30). Subjects' glycemic control will be assessed by an oral glucose tolerance
test (OGTT) at three different time points. One OGTT will occur shortly after consumption of
red wine, the second after consumption of vodka containing the identical amount of ethanol as
the wine treatment, and the third OGTT will occur shortly after consumption of an equal
volume of water. The three OGTTs will be administered in random order.
Inclusion Criteria:
- insulin resistant: diagnosed with pre-diabetes or fasting blood glucose >/= 97 mg/dL
- T2D: diagnosed by primary care physician
- at risk of type 2 diabetes (obesity and physically inactive)
- age: 21-65
Exclusion Criteria:
- smoking
- insulin use (other than once daily)
- physically active (>30 mins aerobic exercise two days/week)
- recent (>3 mo) changes in medication use or dose
- uncontrolled type two diabetes (HbA1C >10%)
- advanced retinopathy or neuropathy
- pregnancy
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University of Missouri T he University of Missouri was founded in 1839 in Columbia, Mo.,...
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