Role of the Foregut in Nutrient Metabolism in Lean and Obese Humans



Status:Enrolling by invitation
Conditions:Obesity Weight Loss
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:20 - 50
Updated:5/24/2018
Start Date:September 2015
End Date:April 2019

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Trial Summary
Trial Overview
Inclusion Criteria
The overall hypothesis of this proposal is that nutrient sensing in the foregut regulates
metabolic hormone secretion and nutrient metabolism via enteric neural signals, and these
mechanisms might be defective in obesity.


Inclusion Criteria:

- BMI 19 - 25 kg/m2 or 30 - 50 kg/m2

- Age 20 - 50 years

Exclusion Criteria:

- Contraindication to a nasoduodenal feeding tube (e.g., deviated nasal septum, prior
upper gastrointestinal bleed, or history of easy bleeding)

- Prior gastric or intestinal surgery or pancreas resection

- Females with a positive pregnancy test

- Known history of intestinal diseases including, but not limited to, inflammatory bowel
disease (e.g. ulcerative colitis, Crohn's disease), celiac sprue

- Type 1 or type 2 diabetes

- Recent presence of or treatment for gastroenteritis (diarrhea and/or vomiting),
constipation, or upper respiratory infection

- Anemia

- Abnormal EKG

- Prior adverse reaction to anesthesia

- Tobacco use
We found this trial at
1
site
Vanderbilt University Medical Center
1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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mi
from
Nashville, TN
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