Follow-Up Study of People Treated for Scoliosis
| Status: | Completed |
|---|---|
| Conditions: | Orthopedic, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 50 - 95 |
| Updated: | 2/17/2019 |
| Start Date: | September 9, 2015 |
| End Date: | August 16, 2016 |
Breast and Other Cancers Following X-Rays for Scoliosis
Background:
Scoliosis is a curving of the spine. It usually happens in girls when they are children and
teens. Doctors often use x-rays to diagnose it. The x-rays give low radiation. This may
increase the risk that those young women get cancer later in life. Researchers want to learn
more about this risk. They will look data that has already been collected.
Objectives:
To study cancer risks of repeated low radiation from x-rays for scoliosis. Also, to study
death risks related to certain scoliosis patient characteristics. These include causes, kinds
of curvature, and kinds of treatment.
Eligibility:
Medical records of women from past scoliosis studies.
Design:
This U.S. Scoliosis Cohort includes more than 5,000 women who were diagnosed between 1912 and
1965.
Data were collected on these women in the 1980s and 1990s. These came from medical records,
radiology log books, and x-ray films. Researchers found out where participants were,
including if they were dead. Some women were given a follow-up questionnaire.
Researchers want to find out where participants are today. They want to identify new deaths
of participants. They want to find out their causes of death. This data will be added to
other databases.
Scoliosis is a curving of the spine. It usually happens in girls when they are children and
teens. Doctors often use x-rays to diagnose it. The x-rays give low radiation. This may
increase the risk that those young women get cancer later in life. Researchers want to learn
more about this risk. They will look data that has already been collected.
Objectives:
To study cancer risks of repeated low radiation from x-rays for scoliosis. Also, to study
death risks related to certain scoliosis patient characteristics. These include causes, kinds
of curvature, and kinds of treatment.
Eligibility:
Medical records of women from past scoliosis studies.
Design:
This U.S. Scoliosis Cohort includes more than 5,000 women who were diagnosed between 1912 and
1965.
Data were collected on these women in the 1980s and 1990s. These came from medical records,
radiology log books, and x-ray films. Researchers found out where participants were,
including if they were dead. Some women were given a follow-up questionnaire.
Researchers want to find out where participants are today. They want to identify new deaths
of participants. They want to find out their causes of death. This data will be added to
other databases.
U.S. Scoliosis Cohort includes 5,573 female spinal deformity (93% scoliosis) patients
diagnosed in any of 14 medical centers in the U.S. during 1912-1965. The primary objective of
this study is to evaluate site-specific cancer risks associated with repeated low-dose
radiation exposures from diagnostic x-rays. A secondary objective is to evaluate late
mortality risks associated with patient characteristics, such as etiology, degree and type of
curvature, and type of treatment. The current proposal is to extend mortality follow-up by 10
years. All patients not known to be deceased will be submitted to the National Death Index
Plus to identify new deaths and obtain causes of death.
A feasibility study was conducted in four medical centers in the Minneapolis-St. Paul,
Minnesota area during 1983-1987. The primary goals of the feasibility study were to ascertain
if an adequate number of patients meeting the study criteria could be identified and located,
medical and radiography records were available and substantially complete, organspecific
radiation doses could be estimated from the available data and were large enough to warrant
further study, and a reasonable percentage of patients would complete a follow-up
questionnaire. The feasibility study was successful in meeting all goals. Enrolled for study
were 1,030 female patients with spinal deformities diagnosed during 1922-1965. Medical
records were abstracted, individual x-ray films were reviewed, patients were located, and
follow-up questionnaire was administered to identify incident cancers. Eleven breast cancers
were reported. Scoliosis patients had an 80% higher breast cancer risk compared to women in
the general population and, based on internal cohort analyses, breast cancer risk increased
with increasing number of x-rays and with estimated radiation dose to the breast.
An expanded study was conducted during 1988-1993. The main goals of the expanded study were
to enlist the collaboration of suitable additional medical centers where large numbers of
spinal deformity patients were treated before 1966, abstract data from medical and radiology
records, trace patients for vital status and current location, obtain information on incident
cancers and cancer risk factors by questionnaire, medically validate reported cancers, and
determine causes of death for decedents. Another 4,543 patients diagnosed during 1912-1965
were enrolled from ten hospitals, bringing the total study population to 5,573 patients.
Compared to women in the general population, spinal deformity patients had statistically
significantly higher risks of dying from breast cancer, and for both incidence and mortality,
breast cancer risk increased with increasing diagnostic radiation exposure to the breast.
Patients also have elevated risks for mortality from all causes, circulatory, respiratory,
nervous system, musculoskeletal, digestive, and infectious & parasitic diseases, primarily
related to degree of spinal curvature. Additional mortality follow-up will enable more
definitive assessments of cancer and other disease risks with radiation and other factors in
these patients.
diagnosed in any of 14 medical centers in the U.S. during 1912-1965. The primary objective of
this study is to evaluate site-specific cancer risks associated with repeated low-dose
radiation exposures from diagnostic x-rays. A secondary objective is to evaluate late
mortality risks associated with patient characteristics, such as etiology, degree and type of
curvature, and type of treatment. The current proposal is to extend mortality follow-up by 10
years. All patients not known to be deceased will be submitted to the National Death Index
Plus to identify new deaths and obtain causes of death.
A feasibility study was conducted in four medical centers in the Minneapolis-St. Paul,
Minnesota area during 1983-1987. The primary goals of the feasibility study were to ascertain
if an adequate number of patients meeting the study criteria could be identified and located,
medical and radiography records were available and substantially complete, organspecific
radiation doses could be estimated from the available data and were large enough to warrant
further study, and a reasonable percentage of patients would complete a follow-up
questionnaire. The feasibility study was successful in meeting all goals. Enrolled for study
were 1,030 female patients with spinal deformities diagnosed during 1922-1965. Medical
records were abstracted, individual x-ray films were reviewed, patients were located, and
follow-up questionnaire was administered to identify incident cancers. Eleven breast cancers
were reported. Scoliosis patients had an 80% higher breast cancer risk compared to women in
the general population and, based on internal cohort analyses, breast cancer risk increased
with increasing number of x-rays and with estimated radiation dose to the breast.
An expanded study was conducted during 1988-1993. The main goals of the expanded study were
to enlist the collaboration of suitable additional medical centers where large numbers of
spinal deformity patients were treated before 1966, abstract data from medical and radiology
records, trace patients for vital status and current location, obtain information on incident
cancers and cancer risk factors by questionnaire, medically validate reported cancers, and
determine causes of death for decedents. Another 4,543 patients diagnosed during 1912-1965
were enrolled from ten hospitals, bringing the total study population to 5,573 patients.
Compared to women in the general population, spinal deformity patients had statistically
significantly higher risks of dying from breast cancer, and for both incidence and mortality,
breast cancer risk increased with increasing diagnostic radiation exposure to the breast.
Patients also have elevated risks for mortality from all causes, circulatory, respiratory,
nervous system, musculoskeletal, digestive, and infectious & parasitic diseases, primarily
related to degree of spinal curvature. Additional mortality follow-up will enable more
definitive assessments of cancer and other disease risks with radiation and other factors in
these patients.
- Data Analysis Only
We found this trial at
1
site
9609 Medical Center Drive
Bethesda, Maryland 20892
Bethesda, Maryland 20892
1-800-422-6237
National Cancer Institute , 9000 Rockville Pike The National Cancer Institute (NCI) is part of...
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