A Novel PET Approach to Measuring Myocardial Metabolism
| Status: | Completed |
|---|---|
| Conditions: | Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 4/21/2016 |
| Start Date: | January 2007 |
| End Date: | June 2009 |
Studies of myocardial fuel selection using a novel palmitate-based PET probe
A novel PET probe, 16- 18-F-fluoro-4-thiapalmitate, will be used to evaluate myocardial atty
acid uptake. Studies will be done in humans with type 2 diabetes mellitus, and in controls.
Studies will take place on 2 separate days, under fasting conditions and under insulin clamp
conditions.
acid uptake. Studies will be done in humans with type 2 diabetes mellitus, and in controls.
Studies will take place on 2 separate days, under fasting conditions and under insulin clamp
conditions.
Inclusion Criteria:
- Lean:
- BMI<25 kg/m2
- normal glucose tolerance by 75g oral glucose tolerance test
- Type 2 diabetes mellitus:
- BMI >25 kg/m2
- previously diagnosed type 2 diabetes mellitus
- on oral and/or injected insulin treatment.
Exclusion Criteria:
- Lean:
*Use of any chronic medications
- Type 2 diabetes mellitus
- known microvascular disease
- known coronary or other macro vascular disease
- use of PPARgamma class antidiabetic agents within 6 months
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