Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA), Post-Surgical Pain |
| Therapuetic Areas: | Musculoskeletal, Rheumatology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/14/2018 |
| Start Date: | October 2015 |
| End Date: | December 2019 |
Do Intraoperative Periarticular Injections Improve Postoperative Pain Control in Patients Receiving Duramorph (Preservative Free) During Total Knee Arthroplasty? A Prospective, Double-Blind, Randomized Controlled Trial
This study will evaluate the use of a local injection around the knee (periarticular) during
total knee replacement (TKR) surgery to see if it reduces postoperative pain levels. The
injection is a combination of various medications which are thought to reduce pain levels.
Approximately 128 patients will participate in this study, half of the patients will receive
this injection during surgery and the other half will receive a saline (salt water)
injection. Pain scores after the surgery will be compared between the two groups.
All patients will also receive a long-acting (24 hours) morphine injection during surgery.
The hypothesis is that those participants receiving intrathecal Duramorph and local
periarticular injections will have improved pain scores and reduced narcotic use when
compared with intrathecal Duramorph alone at 48 hours postoperatively.
total knee replacement (TKR) surgery to see if it reduces postoperative pain levels. The
injection is a combination of various medications which are thought to reduce pain levels.
Approximately 128 patients will participate in this study, half of the patients will receive
this injection during surgery and the other half will receive a saline (salt water)
injection. Pain scores after the surgery will be compared between the two groups.
All patients will also receive a long-acting (24 hours) morphine injection during surgery.
The hypothesis is that those participants receiving intrathecal Duramorph and local
periarticular injections will have improved pain scores and reduced narcotic use when
compared with intrathecal Duramorph alone at 48 hours postoperatively.
Data Collection:
Data will be collected from the patient's medical record after discharge
Variables include:
- Age
- Sex
- BMI
- UPAT score (Universal Pain Assessment Tool)- this is assessed hourly postoperatively by
nursing staff on Orthopedics Unit
- Patient's assessment of acceptability of pain
- UPAT score as assessed by physical therapy pre and post therapy sessions
- Duramorph dose
- Time patient arrived on the Orthopedic Unit
- Length of ambulation during physical therapy sessions
- Amount of supplementary opioids (measured in morphine equivalents)
- Use of anti-emetics
- Any complications of surgery including venous thromboembolic event, cardiac event,
bleeding event
- Length of hospital stay
The pharmacist will randomize patients to either study arm, prepare the injection and
maintain dispensing records.
Data will be collected from the patient's medical record after discharge
Variables include:
- Age
- Sex
- BMI
- UPAT score (Universal Pain Assessment Tool)- this is assessed hourly postoperatively by
nursing staff on Orthopedics Unit
- Patient's assessment of acceptability of pain
- UPAT score as assessed by physical therapy pre and post therapy sessions
- Duramorph dose
- Time patient arrived on the Orthopedic Unit
- Length of ambulation during physical therapy sessions
- Amount of supplementary opioids (measured in morphine equivalents)
- Use of anti-emetics
- Any complications of surgery including venous thromboembolic event, cardiac event,
bleeding event
- Length of hospital stay
The pharmacist will randomize patients to either study arm, prepare the injection and
maintain dispensing records.
Inclusion Criteria:
- Age 18 or older
- Written informed consent
Exclusion Criteria:
- Pregnant women
- Creatinine clearance less than 60 ml/min
- BMI greater than 40
- Currently use greater than 80mg morphine-equivalents daily (pre-operatively)
- Receive a unicondylar knee replacement
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Virginia Commonwealth University Since our founding as a medical school in 1838, Virginia Commonwealth University...
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