Evaluation of Salt Sensitivity in Young Adults
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 21 - 30 |
| Updated: | 5/20/2016 |
| Start Date: | May 2012 |
| End Date: | March 2015 |
The current prospective cross-sectional pilot study is proposed to determine a set of
characteristic factors associated with salt sensitivity in young adults by measuring blood
pressure, serum aldosterone levels, urine analysis, arterial pulse wave velocity and central
arterial pressure in response to short term increases in salt intake.
characteristic factors associated with salt sensitivity in young adults by measuring blood
pressure, serum aldosterone levels, urine analysis, arterial pulse wave velocity and central
arterial pressure in response to short term increases in salt intake.
Since salt sensitivity at an early age is associated with subsequent hypertension and an
increase in mortality, intervention by lifestyle modification including the reduction of
sodium intake could prevent subsequent increases in blood pressure and development of
hypertension, cardiovascular disease and death. It would therefore be beneficial to have a
simple method of identifying salt sensitive young adults so that risk factor modification
can be achieved to prevent progression of the effects of hypertension on heart function.
This study is a longitudinal pilot study to identify characteristics of salt sensitive young
adults so that this population of people can be identified early on and appropriate
lifestyle modifications can be made to prevent the subsequent progression of hypertension
and cardiovascular disease.
The study will be conducted at 2 visits separated by one week. At the first visit, eligible
subjects will be asked to complete questionnaires regarding childhood and current sodium
intake.Subjects will be asked about family history of hypertension and cardiovascular
disease. Subjects will also undergo blood pressure measurement in both arm, and will provide
a blood sample and spot urine sample. Subjects will then be asked to take salt pills 3 times
a day for one week, and then return to the study center for a repeat of the above
measurements.
increase in mortality, intervention by lifestyle modification including the reduction of
sodium intake could prevent subsequent increases in blood pressure and development of
hypertension, cardiovascular disease and death. It would therefore be beneficial to have a
simple method of identifying salt sensitive young adults so that risk factor modification
can be achieved to prevent progression of the effects of hypertension on heart function.
This study is a longitudinal pilot study to identify characteristics of salt sensitive young
adults so that this population of people can be identified early on and appropriate
lifestyle modifications can be made to prevent the subsequent progression of hypertension
and cardiovascular disease.
The study will be conducted at 2 visits separated by one week. At the first visit, eligible
subjects will be asked to complete questionnaires regarding childhood and current sodium
intake.Subjects will be asked about family history of hypertension and cardiovascular
disease. Subjects will also undergo blood pressure measurement in both arm, and will provide
a blood sample and spot urine sample. Subjects will then be asked to take salt pills 3 times
a day for one week, and then return to the study center for a repeat of the above
measurements.
Inclusion Criteria:
- Young adults age 21-30
- Able and willing to provide written informed consent
Exclusion Criteria:
- Any cardiovascular or other chronic health problem
- Chronic medications besides oral contraceptive pills in women
- BMI>30kg/m2
- Blood pressure >140/90 mmHg
- Inability or unwillingness to adhere to study procedures
We found this trial at
1
site
Click here to add this to my saved trials
