The Effect of Diluted Sodium Hypochlorite Solution and Moisturizers on Skin Barrier Function in Atopic Dermatitis
| Status: | Completed |
|---|---|
| Conditions: | Psoriasis, Dermatology, Dermatology, Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | 8 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | January 2014 |
| End Date: | May 2015 |
The goal is this study is to investigate the effects of dilute bleach on the skin of
subjects with atopic dermatitis and those with healthy skin. The second goal is to evaluate
the effects of different moisturizers on the skin barrier of subjects with and without
atopic dermatitis. The investigators hypothesize that the bleach bath will increase the skin
pH, decrease the skin hydration, and increase skin water loss in all study subjects.
Secondly, the investigators hypothesize that moisturizers with the lowest pH and the highest
water to oil ratio will result in improved skin barrier function. Furthermore, the
investigators believe there will be a greater improvement in patients with atopic
dermatitis.
subjects with atopic dermatitis and those with healthy skin. The second goal is to evaluate
the effects of different moisturizers on the skin barrier of subjects with and without
atopic dermatitis. The investigators hypothesize that the bleach bath will increase the skin
pH, decrease the skin hydration, and increase skin water loss in all study subjects.
Secondly, the investigators hypothesize that moisturizers with the lowest pH and the highest
water to oil ratio will result in improved skin barrier function. Furthermore, the
investigators believe there will be a greater improvement in patients with atopic
dermatitis.
The study has two main parts. Subjects in both groups will have one forearm in a dilute
bleach bath and the other arm in a water bath for 10 minutes. The change in skin will be
measured using different painless devices. The second part of the study involves application
of 4 various moisturizers. The change in skin will be measured over a period of time using
the non-invasive devices.
bleach bath and the other arm in a water bath for 10 minutes. The change in skin will be
measured using different painless devices. The second part of the study involves application
of 4 various moisturizers. The change in skin will be measured over a period of time using
the non-invasive devices.
Inclusion Criteria:
- Age 8 years to 65 years
- Has been diagnosed with atopic dermatitis by a board-certified dermatologist at UC
Davis
- Subject/parents/legal guardians able to read and comprehend the study procedure and
consent forms.
Exclusion Criteria:
- Those who are pregnant, prisoners, or cognitively impaired
- Those who do not fit the inclusion criteria
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