Water Drinking Test in Patients With Occludable Angle
| Status: | Completed |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 21 - 90 |
| Updated: | 12/2/2017 |
| Start Date: | February 2010 |
| End Date: | January 2015 |
What is the Effect of the "Water Drinking Test" on Patients With Narrow Angles on the Day of Their Scheduled Laser Iridotomy?
The water drinking test (WDT), is a predictive test that has been used to detect primary open
angle glaucoma and recently has been demonstrated as a predictor of the diurnal tension
curve. Clinically accurate provocative tests for asymptomatic eyes with shallow anterior
chambers and narrow angles are highly desirable to detect patients prone to angle closure
glaucoma. The aim of this pilot study is to evaluate the possible role of water drinking test
in patients with narrow angles who are scheduled for prophylactic laser iridotomy.
angle glaucoma and recently has been demonstrated as a predictor of the diurnal tension
curve. Clinically accurate provocative tests for asymptomatic eyes with shallow anterior
chambers and narrow angles are highly desirable to detect patients prone to angle closure
glaucoma. The aim of this pilot study is to evaluate the possible role of water drinking test
in patients with narrow angles who are scheduled for prophylactic laser iridotomy.
This prospective case series will investigate the effects of the WDT on subjects with narrow
anterior chamber angles on the day of their scheduled laser iridotomy. The angle
configuration and IOP will be monitored following the WDT. Twenty patients with occludable
angles will be enrolled in this study. After measuring the baseline IOP, weight and height,
the patients will be asked to drink 10ml/kg water over 15 minutes (equal to approximately
0.33 ounces of water for every 2.2 pounds of weight or 2 ½ cups for a 150 lb. individual) and
their IOP will be checked every 15 minutes up to one hour after drinking the water. This will
be repeated after performing a laser iridotomy. The data obtained, mainly IOP and gonioscopic
findings, will be analyzed using statistical tests and compared to historical controls of the
WDT without narrow angles, and laser iridotomy subjects without the WDT.
anterior chamber angles on the day of their scheduled laser iridotomy. The angle
configuration and IOP will be monitored following the WDT. Twenty patients with occludable
angles will be enrolled in this study. After measuring the baseline IOP, weight and height,
the patients will be asked to drink 10ml/kg water over 15 minutes (equal to approximately
0.33 ounces of water for every 2.2 pounds of weight or 2 ½ cups for a 150 lb. individual) and
their IOP will be checked every 15 minutes up to one hour after drinking the water. This will
be repeated after performing a laser iridotomy. The data obtained, mainly IOP and gonioscopic
findings, will be analyzed using statistical tests and compared to historical controls of the
WDT without narrow angles, and laser iridotomy subjects without the WDT.
Inclusion Criteria:
- narrow angle judged to be at risk of attack by the treating physician, with one or
more quadrants not open to the sclera spur on gonioscopy
- age between 21 and 90 years
- ability to give informed consent.
Exclusion Criteria:
- baseline IOP higher than 21 mm Hg with or without medication
- other causes of glaucoma, such as pseudoexfoliative and pigmentary glaucomas
- previous treatment with argon laser or selective laser trabeculoplasty
- previous refractive sugary; (5) pregnant women; (6) congestive heart failure
- renal failure or urinary retention issues; (8) corneal abnormalities preventing
reliable IOP measurement
- non-glaucomatous optic neuropathy
- prior refractive surgery or other issues preventing accurate Goldmann applanation
tonometry
- prior intraocular surgery
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