Multicomponent Yoga Intervention for Major Depressive Disorder
| Status: | Completed |
|---|---|
| Conditions: | Depression, Depression, Major Depression Disorder (MDD) |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 67 |
| Updated: | 4/21/2016 |
| Start Date: | October 2014 |
| End Date: | December 2015 |
A Randomized Study of a Comprehensive Yoga Intervention for Patients With Major Depressive Disorder With Incomplete Response to Antidepressants
The purpose of this study is to evaluate the efficacy of a multi-component yoga intervention
featuring Sudarshan Kriya Yoga (SKY) as an adjunctive treatment for patients with Major
Depressive Disorders with incomplete response to antidepressants.
featuring Sudarshan Kriya Yoga (SKY) as an adjunctive treatment for patients with Major
Depressive Disorders with incomplete response to antidepressants.
According to the World Health Organization, compared to two hundred health conditions,
depression is ranked as the second leading cause of disability worldwide. The annual
prevalence of Major Depressive Disorder (MDD) in the United States is estimated at 7% and
the lifetime risk approximately 17%. Depression is associated with approximately 75% of all
deaths by suicide, resulting in immense suffering for families and society at large. 83
billion dollars are spent per year on treatment and lost productivity related to the
disorder. Current treatments for MDD have remission rates between 35-50%. Patients who
respond to treatment, but do not experience clinical remission are at markedly increased
risk for relapse. Approximately 50% of patients treated with two trials of antidepressant
interventions do not achieve clinical remission. Consequently, novel evidence-based
treatment modalities that can further treat this devastating disorder are needed. Mind-body
interventions constitute a large and diverse group of practices that reduce both stress and
inflammation and are increasingly being evaluated in the treatment of MDD The 2007 NHIS
concluded that 16.6% of U.S. adults, representing 34.1 million Americans, used at least one
mind-body intervention in the past year. Initial studies with different mind-body
interventions have been shown to improve outcomes in MDD. A recent meta-analysis gave a
Grade B for current evidence for the use of yoga as an intervention for MDD. Sudarshan Kriya
Yoga (SKY) is a advanced yogic breathing intervention that has been reported to relieve
symptoms of major depressive disorder and generalized anxiety disorder. In MDD, SKY can
correct the P300 amplitude, decrease plasma cortisol levels and increase plasma prolactin
levels. In a small-scale randomized controlled trial, 45 consenting inpatients meeting
criteria for DSM-IV severe, melancholic depression were randomized to receive SKY,
electroconvulsive therapy (ECT) or imipramine treatment for four weeks (Janakiramaiah et al.
2000). Consequently, the rigorous evaluation of a multicomponent yogic intervention
featuring SKY as an adjunctive treatment for adults with MDD warrants further study.
depression is ranked as the second leading cause of disability worldwide. The annual
prevalence of Major Depressive Disorder (MDD) in the United States is estimated at 7% and
the lifetime risk approximately 17%. Depression is associated with approximately 75% of all
deaths by suicide, resulting in immense suffering for families and society at large. 83
billion dollars are spent per year on treatment and lost productivity related to the
disorder. Current treatments for MDD have remission rates between 35-50%. Patients who
respond to treatment, but do not experience clinical remission are at markedly increased
risk for relapse. Approximately 50% of patients treated with two trials of antidepressant
interventions do not achieve clinical remission. Consequently, novel evidence-based
treatment modalities that can further treat this devastating disorder are needed. Mind-body
interventions constitute a large and diverse group of practices that reduce both stress and
inflammation and are increasingly being evaluated in the treatment of MDD The 2007 NHIS
concluded that 16.6% of U.S. adults, representing 34.1 million Americans, used at least one
mind-body intervention in the past year. Initial studies with different mind-body
interventions have been shown to improve outcomes in MDD. A recent meta-analysis gave a
Grade B for current evidence for the use of yoga as an intervention for MDD. Sudarshan Kriya
Yoga (SKY) is a advanced yogic breathing intervention that has been reported to relieve
symptoms of major depressive disorder and generalized anxiety disorder. In MDD, SKY can
correct the P300 amplitude, decrease plasma cortisol levels and increase plasma prolactin
levels. In a small-scale randomized controlled trial, 45 consenting inpatients meeting
criteria for DSM-IV severe, melancholic depression were randomized to receive SKY,
electroconvulsive therapy (ECT) or imipramine treatment for four weeks (Janakiramaiah et al.
2000). Consequently, the rigorous evaluation of a multicomponent yogic intervention
featuring SKY as an adjunctive treatment for adults with MDD warrants further study.
Inclusion Criteria:
- DSM-IV Major Depressive Disorder
- Able to give informed consent
- Aged 18-67
- Currently in outpatient care for MDD
- On a stable antidepressant regimen for at least 2 months
- 17-item Hamilton Depression Score >14 at screening & baseline visit
Exclusion Criteria:
- Currently in crisis requiring inpatient treatment
- Bipolar Disorder, Psychotic Disorder, ADHD, Substance Use Disorder
- Pregnancy, Epilepsy
- Initiating psychotherapy or other yoga/meditation program
We found this trial at
1
site
Click here to add this to my saved trials
