Innate Immune Response in COPD
| Status: | Completed |
|---|---|
| Conditions: | Bronchitis, Chronic Obstructive Pulmonary Disease |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 50 - 89 |
| Updated: | 4/21/2016 |
| Start Date: | March 2006 |
| End Date: | January 2008 |
The purpose of this study is to determine whether the response of the immune system to
bacterial components differs between patients with severe COPD compared to those with less
severe COPD.
bacterial components differs between patients with severe COPD compared to those with less
severe COPD.
The airways of COPD patients are often colonized with bacteria leading to increased airway
inflammation. This study sought to determine whether systemic cytokine responses to
microbial pathogen-associated molecular patterns (PAMPs) are increased among subjects with
severe COPD.
In an observational cross-sectional study of COPD subjects, PAMP-induced cytokine responses
were measured in whole blood ex vivo. We used PAMPs derived from microbial products
recognized by TLR 1, 2, 4, 5, 6, 7, and 8. Patterns of cytokine response to PAMPs were
assessed using hierarchical clustering. One-sided t-tests were used to compare PAMP-induced
cytokine levels in blood from patients with and without severe COPD, and for subjects with
and without chronic bronchitis.
inflammation. This study sought to determine whether systemic cytokine responses to
microbial pathogen-associated molecular patterns (PAMPs) are increased among subjects with
severe COPD.
In an observational cross-sectional study of COPD subjects, PAMP-induced cytokine responses
were measured in whole blood ex vivo. We used PAMPs derived from microbial products
recognized by TLR 1, 2, 4, 5, 6, 7, and 8. Patterns of cytokine response to PAMPs were
assessed using hierarchical clustering. One-sided t-tests were used to compare PAMP-induced
cytokine levels in blood from patients with and without severe COPD, and for subjects with
and without chronic bronchitis.
Inclusion Criteria:
- post-bronchodilator FEV1/FVC <0.7
- FEV1 < 80%
- > 10 pack-years tobacco smoking
- no respiratory illnesses or prednisone or antibiotics in the last 4 weeks
Exclusion Criteria:
- Primary diagnosis of asthma
- > 15% change in FEV1
- Chronic inflammatory or infectious disease
- Cancer
- Autoimmune disease
- Chronic renal failure with a creatinine > 1.5
- Chronic liver disease
- Chronic antibiotic use
Note: Due to difficulty recruiting patients after 6 participants were enrolled, the
exclusion criteria were modified to allow patients with > 15% change in FEV1. The
exclusion criteria were also changed to allow chronic renal failure not requiring
dialysis, and non-metastatic cancer provided there was no diagnosis of lung cancer.
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