Adverse Health Effects of Mainstream and Secondhand Hookah Smoke in NYC Hookah Bars
| Status: | Completed |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 4/21/2016 |
| Start Date: | July 2014 |
| End Date: | September 2015 |
The primary purpose of this study is to examine the health effects of mainstream and
secondhand hookah (i.e. water pipe) smoke on pulmonary and cardiovascular functions as well
as serum levels of inflammatory biomarkers. Investigators would like to demonstrate that
inhalation of both mainstream and secondhand smoke generated by hookah produces adverse
pulmonary and cardiovascular effects and alterations in serum levels of inflammatory
biomarkers.
secondhand hookah (i.e. water pipe) smoke on pulmonary and cardiovascular functions as well
as serum levels of inflammatory biomarkers. Investigators would like to demonstrate that
inhalation of both mainstream and secondhand smoke generated by hookah produces adverse
pulmonary and cardiovascular effects and alterations in serum levels of inflammatory
biomarkers.
A total of 20 participants are going to be enrolled in this study; 10 participants smoke
hookah and 10 participants are exposed to second hand hookah smoke for 2 hours in NYC hookah
bars. Subjects in the control group will also be paired as they were for the hookah bar
visit but will visit a control location, where they will be asked to consume a similar
amount of food and drink at a wine bar. Pulmonary function, cardiovascular changes, and
blood and urine markers of inflammatory mediators before, immediately after and 24 hours
after the participants' visits to hookah bars and wine bars will be examined. Air quality
monitoring will also be performed at the hookah bar and at the control location.
Physiological changes will be assessed by measuring pulmonary function, blood pressure,
heart rate, and blood oxygenation status. To determine the extent of tobacco exposure and
associated inflammatory changes from secondhand hookah smoke, investigators will measure
blood inflammatory biomarkers, oxidative stress, gene expression, tobacco-related
carcinogenic metabolites, and exhaled carbon dioxide levels.
hookah and 10 participants are exposed to second hand hookah smoke for 2 hours in NYC hookah
bars. Subjects in the control group will also be paired as they were for the hookah bar
visit but will visit a control location, where they will be asked to consume a similar
amount of food and drink at a wine bar. Pulmonary function, cardiovascular changes, and
blood and urine markers of inflammatory mediators before, immediately after and 24 hours
after the participants' visits to hookah bars and wine bars will be examined. Air quality
monitoring will also be performed at the hookah bar and at the control location.
Physiological changes will be assessed by measuring pulmonary function, blood pressure,
heart rate, and blood oxygenation status. To determine the extent of tobacco exposure and
associated inflammatory changes from secondhand hookah smoke, investigators will measure
blood inflammatory biomarkers, oxidative stress, gene expression, tobacco-related
carcinogenic metabolites, and exhaled carbon dioxide levels.
Inclusion Criteria:
- Competent adult English speaking subjects
- Have used hookah in the past
Exclusion Criteria:
- Age <21
- Pregnancy
- Current cigarette smokers
- Has pulmonary disease, such as asthma or Chronic Obstructive Pulmonary Disease (COPD)
- Subjects are unable to give voluntary informed consent because they are non English
speaking, are unable to read or write, or any other impediments that prohibits giving
written informed consent
- Recent nasal surgery (within 6 months)
- History of bleeding or other blood related disorder.
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