Clinical Endpoint Bioequivalence Study for Fluticasone Propionate and Salmeterol Xinafoate

The primary objective of this study is to evaluate the clinical bioequivalence of generic
fluticasone propionate 100 µg and salmeterol xinafoate 50 µg inhalation powder (test) to
Advair Diskus ("Advair") 100/50 (reference) for the treatment of asthma.

The secondary objectives of the study are:

- To demonstrate statistical superiority of generic fluticasone propionate 100 µg and
salmeterol xinafoate 50 µg inhalation powder to placebo.

- To demonstrate statistical superiority of Advair 100/50 to placebo.

- To investigate the safety and tolerability of fluticasone propionate 100 µg and
salmeterol xinafoate 50 µg inhalation powder compared with Advair 100/50 in the target
population.

Inclusion Criteria:

1. Male and female subjects must be 12 years of age or older. Females must be of
non-childbearing potential or if of childbearing potential, must commit to consistent
use of a form of birth control which is medically effective.

2. Be able to provide written informed consent or, in the case of adolescents, informed
assent in addition to an informed consent form signed by the adolescent's parent(s) or
legal guardian(s).

3. Be current non-smokers and also may not have used tobacco products (e.g., cigarettes,
cigars, pipe tobacco) within the year prior to Visit 1, and have 10 years or less (10
pack-years for cigarettes) of historical use.

4. Have persistent asthma, as defined by the National Asthma Education and Prevention
Program, for at least 12 weeks before Visit 1.

5. The forced expiratory volume at one second ("FEV1") range required for enrollment is
dependent on whether the subject is an adult or adolescent and whether he or she is
currently treated with inhaled corticosteroids ("ICS") at Visit 1

6. Demonstrate 15% or greater reversibility of FEV1 between 10 and 30 minutes following
360 µg of albuterol inhalation. NOTE: If the subject does not meet criterion 6 at
Visit 1 (Day -14), this criterion must be met at Visit 2 (Day -1).

7. Be able to discontinue controller asthma medication (including leukotriene modifiers
("LTM"), ICS and long acting β-agonists (LABAs)) during the Run-in Period and
Treatment Period.

8. Be able to replace current short-acting β-agonists (SABAs) with the study-supplied
albuterol (or equivalent) rescue medication inhaler for use as needed for the duration
of the study (subjects should be able to withhold all inhaled SABAs for a least 6
hours before lung function assessments during study visits).

9. Be appropriately using 1 of the following asthma-treatment regimens and meet the
associated criteria:

- Low- to medium-dose ICS for at least 4 weeks before Visit 1, with or without an
adjunctive asthma therapy (i.e., LABA, LTM, or theophylline). Both the ICS dose
and overall daily asthma regimen must have been stable for the 4 weeks before
Visit 1; or

- Leukotriene modifier (such as montelukast, zafirlukast, or pranlukast) or
theophylline as monotherapy at a stable dose for at least 4 weeks before Visit
1;or

- Daily (or near daily) rescue medication (e.g., albuterol/ salbutamol or other
inhaled SABA used to treat acute asthma) in the 4 weeks before Visit 1.

10. Must not have been treated (for any reason) with oral or parenteral corticosteroids
for at least 1 month before Visit 1 and must not have used oral SABAs for at least 12
hours before Visit 1 and for the remainder of the study. Routine use of
oral/parenteral corticosteroids and oral SABAs is not allowed after Visit 1.

11. Subjects may continue using short-acting forms of theophylline (withheld at least 12
hours before a site visit), twice daily controlled release forms of theophylline
(withheld at least 24 hours before a site visit), and once daily controlled-release
forms of theophylline (withheld at least 36 hours before a site visit).

12. Be able to answer questions regarding asthma status and be able to document) device
usage and asthma status on a twice daily basis.

NOTE: Placebo inhaler use (i.e., compliance) must be at least 75% of the planned doses
taken as assessed at Visit 2, for the subject to be considered eligible to continue in
the study.

13. Demonstrate proper use of metered dose inhaler ("MDI") and dry-powder inhaler devices.

Exclusion Criteria:

1. Have an Asthma Control Questionnaire (ACQ) score of 3.0 or greater at Visit 1.

2. Are unable to discontinue ICS, LABA, or LTM.

3. Have a history of life-threatening asthma, defined as an asthma episode (at any time
in the past) associated with any of the following: respiratory arrest or intubation,
hypercapnia, hypoxic seizures, or syncopal episode.

4. Have exercise-induced asthma as the only asthma-related diagnosis that does not
require daily asthma control medicine.

5. Have evidence or history of clinically significant disease or abnormality including
congestive heart failure, uncontrolled hypertension, uncontrolled coronary artery
disease, myocardial infarction, or cardiac dysrhythmia. In addition, historical or
current evidence of significant hematologic, hepatic, neurologic, psychiatric, renal,
or other diseases that in the opinion of the investigator, would put the subject at
risk through study participation, or would affect the study analyses if the disease
exacerbated during the study.

6. Have current clinical evidence of pneumonia, pneumothorax, atelectasis, pulmonary
fibrotic disease, allergic bronchopulmonary aspergillosis, cystic fibrosis,
bronchopulmonary dysplasia, chronic obstructive pulmonary disease, or other
respiratory abnormalities other than asthma.

7. Have obstructive sleep apnea severe enough to require biphasic or continuous
positive-airway pressure therapy, or likely to interfere with the assessment of asthma
symptoms, in the investigator's judgment.

8. Using medication with the potential to affect the course of asthma or interact with
sympathomimetic amines (e.g., β blockers [including eye drops], oral decongestants,
benzodiazepines, digitalis, phenothiazines, polycyclic antidepressants, monoamine
oxidase inhibitors).

9. Had a viral or bacterial, upper or lower respiratory tract infection or sinus or
middle ear infection within 4 weeks before Visit 1 or have an infection during the
Run-in Period.

10. Participated in an interventional study or used any investigational drug for any
disease within 30 days (or 4 half lives, if this is longer than 30 days) before Visit
1 before Visit 1.

11. Used an anti-immunoglobulin E (e.g., omalizumab) or any other monoclonal antibody for
any reason within 6 months before Visit 1.

12. Are hypersensitive to any β2-agonist sympathomimetic drug, or any intranasal, inhaled,
or systemic corticosteroid therapy or any component of these combination medications
including severe milk protein hypersensitivity.

13. Are exhibiting any factors (e.g., infirmity, disability, or geographic location,
inability to follow instructions or study compliance requirements) that the
investigator believes would likely limit the subject's compliance with the study
protocol or scheduled site visits. This includes recent history of substance abuse or
uncontrolled psychiatric or neurological behavior that would render the subject
incapable of reliably following study requirements, in the judgment of the
investigator.

14. Have an affiliation with the participating site; in other words, subject may not be an
immediate family member of any study site staff and may not be employed directly or
indirectly by the study site.