1-Day Study to Evaluate the Safety and Effectiveness of the Intranasal Lacrimal Neurostimulator

This is a prospective, randomized, controlled, double-masked, multicenter clinical trial in
which subjects with aqueous tear deficiency will receive three different device applications
in a randomized sequence.

Inclusion Criteria:

- Subjects with aqueous tear deficiency

- Literate, able to speak English or Spanish, and able to complete questionnaires
independently

- Willing to sign the informed consent and deemed capable of complying with the
requirements of the study protocol

Exclusion Criteria:

- Chronic or recurrent epistaxis, coagulation disorders or other conditions that, in
the opinion of the investigator, may lead to clinically significant increased
bleeding

- Nasal or sinus surgery including nasal cautery or significant trauma

- Cardiac demand pacemaker, implanted defibrillator or other implanted electronic
device

- Diagnosis of epilepsy

- Corneal transplant in either or both eyes

- Participation in any clinical trial with a new active substance or a new device
within 30 days of the Screening Visit

- A woman who is pregnant, planning a pregnancy, or nursing at the Screening Visit