Metabolic Adaptations in Response to High Intensity Interval Training in Obese Adults
| Status: | Recruiting |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 1/23/2019 |
| Start Date: | March 2016 |
| End Date: | January 2025 |
| Contact: | Suzette Howton |
| Email: | suzetter@med.umich.edu |
| Phone: | 734-647-9850 |
The overall objectives are to:
1. Assess mechanisms underlying HIIT-induced improvements in insulin resistance at the
whole-body, tissue, and cellular levels.
2. Systematically compare different HIIT regimens to help identify effective "doses" of
HIIT that may be optimal for improving metabolic health in obese adults.
3. Assess the ability/willingness of obese subjects to adhere to a long-term HIIT program.
Findings from these studies will greatly expand knowledge about the effects of HIIT on
metabolic health, and will provide valuable information for development of programs aimed at
maximizing key metabolic benefits of exercise.
1. Assess mechanisms underlying HIIT-induced improvements in insulin resistance at the
whole-body, tissue, and cellular levels.
2. Systematically compare different HIIT regimens to help identify effective "doses" of
HIIT that may be optimal for improving metabolic health in obese adults.
3. Assess the ability/willingness of obese subjects to adhere to a long-term HIIT program.
Findings from these studies will greatly expand knowledge about the effects of HIIT on
metabolic health, and will provide valuable information for development of programs aimed at
maximizing key metabolic benefits of exercise.
If subjects are eligible for the study, they will be randomized into one of four different
exercise training groups. Before training (and twice after 3 months of training) subjects
will participate in a "clinical study" in which they will be required to stay overnight in
the hospital. During the clinical study, the research team will perform a series of metabolic
tests. Before and after the 3 months of training, the research team will assess subjects
"free-living" 24h blood sugar control using a Continuous Glucose Monitor (CGM). The research
team will measure several other relevant clinical markers (e.g., whole body and regional body
fat assessments [Dual Energy X-ray Absorptiometry (DEXA) and Magnetic Resonance Imager
(MRI)], hepatic lipid accumulation [MRI analysis], blood lipid profile, resting metabolic
rate, glycated hemoglobin [hemoglobin A1c]). After the first 3 months of training, adherence
to the subjects assigned training program will be tracked for the next 9 months (1 year of
training in total). One year after initiating a training program, subjects will be asked to
return to the clinic for a quick follow-up visit where the research team will complete some
standard clinical assessments (e.g., body weight, body composition, blood pressure, and a
blood sample).
exercise training groups. Before training (and twice after 3 months of training) subjects
will participate in a "clinical study" in which they will be required to stay overnight in
the hospital. During the clinical study, the research team will perform a series of metabolic
tests. Before and after the 3 months of training, the research team will assess subjects
"free-living" 24h blood sugar control using a Continuous Glucose Monitor (CGM). The research
team will measure several other relevant clinical markers (e.g., whole body and regional body
fat assessments [Dual Energy X-ray Absorptiometry (DEXA) and Magnetic Resonance Imager
(MRI)], hepatic lipid accumulation [MRI analysis], blood lipid profile, resting metabolic
rate, glycated hemoglobin [hemoglobin A1c]). After the first 3 months of training, adherence
to the subjects assigned training program will be tracked for the next 9 months (1 year of
training in total). One year after initiating a training program, subjects will be asked to
return to the clinic for a quick follow-up visit where the research team will complete some
standard clinical assessments (e.g., body weight, body composition, blood pressure, and a
blood sample).
Inclusion Criteria:
- Age: 18-40
- Body Mass Index: 30-40 kg/m2
- Waist circumference: 88-98cm for women and 100-110cm for men
- Glucose intolerant (i.e., 2h glucose concentration during a screening oral glucose
tolerance test (OGTT)= 140-199mg/dl
- No regularly planned exercise/physical activity
- Women must have regularly occurring menses and must be premenopausal
Exclusion Criteria:
- EKG abnormalities as assessed by the cardiologist on the research team
- Evidence/history of cardiovascular or metabolic disease
- Medications known to affect lipid or glucose metabolism
- Pregnant or lactating
- Tobacco or e-cigarette use
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