Blood Volume Analysis and Renal Outcomes in Hemodialysis
| Status: | Completed |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease, Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 4/21/2016 |
| Start Date: | January 2014 |
| End Date: | January 2015 |
The objective of the proposed study is to demonstrate that serial blood volume analysis
(BVA) using RI-BVA (BVA-100, Daxor, NY) can be used to guide changes in prescription of dry
weight for hemodialysis patients. The knowledge of a patient's ideal BV and degree of
hypervolemia using these measurements can be used to change the prescription of DW in an
objective way instead of the current standard of practice, which is based on subjective
prescription of dry weight. A first study was conducted to determine the rate of plasma
volume (PV) re-expansion for each patient as a guide to rate of fluid removal (results
published, refer to citations). A second study was conducted in order to assess the value of
a BVA measurement in guiding prescription of clinical DW. A follow up BVA would then be done
in order to check if patients were closer to ideal BV than prior to changing dry weight.
(BVA) using RI-BVA (BVA-100, Daxor, NY) can be used to guide changes in prescription of dry
weight for hemodialysis patients. The knowledge of a patient's ideal BV and degree of
hypervolemia using these measurements can be used to change the prescription of DW in an
objective way instead of the current standard of practice, which is based on subjective
prescription of dry weight. A first study was conducted to determine the rate of plasma
volume (PV) re-expansion for each patient as a guide to rate of fluid removal (results
published, refer to citations). A second study was conducted in order to assess the value of
a BVA measurement in guiding prescription of clinical DW. A follow up BVA would then be done
in order to check if patients were closer to ideal BV than prior to changing dry weight.
In the first study the investigators demonstrated that BV measurement using BVA-100 is
useful to determine absolute BV as well as changes in BV and correlates reasonably well with
CLM-III measurements. Individual refilling ability can be determined as well. This may prove
useful in prescribing and monitoring ultrafiltration rates, establishment of optimal BV in
HD patients and reducing morbidity and mortality associated with chronic HD.
In the current study the investigators hypothesize that BVA can be used in the longer term
to evaluate the adequacy of the current clinically estimated dry weight in dialysis patients
and can be used to titrate EDW in order to improve overall volume status and decrease the
incidence of blood volume misinterpretation. The investigators enrolled 12 eligible
patients. Participants underwent post-hemodialysis blood volume analysis (BVA) as a baseline
measurement. Based on their Blood Volume (BV) status, their prescribed estimated dry weight
(EDW) was adjusted. After 3 to 6 months, participants underwent a repeat BV measurement. The
investigators compared the second value to the first in order to judge whether an
improvement in BV status occurred if the dry weight prescription was changed, or to judge
stability if it was not.
useful to determine absolute BV as well as changes in BV and correlates reasonably well with
CLM-III measurements. Individual refilling ability can be determined as well. This may prove
useful in prescribing and monitoring ultrafiltration rates, establishment of optimal BV in
HD patients and reducing morbidity and mortality associated with chronic HD.
In the current study the investigators hypothesize that BVA can be used in the longer term
to evaluate the adequacy of the current clinically estimated dry weight in dialysis patients
and can be used to titrate EDW in order to improve overall volume status and decrease the
incidence of blood volume misinterpretation. The investigators enrolled 12 eligible
patients. Participants underwent post-hemodialysis blood volume analysis (BVA) as a baseline
measurement. Based on their Blood Volume (BV) status, their prescribed estimated dry weight
(EDW) was adjusted. After 3 to 6 months, participants underwent a repeat BV measurement. The
investigators compared the second value to the first in order to judge whether an
improvement in BV status occurred if the dry weight prescription was changed, or to judge
stability if it was not.
Inclusion Criteria:
- Age >21 years
- Primary diagnosis of either chronic or acute kidney disease
- Currently receiving HD treatment
- Thrice-weekly or twice-weekly HD schedule
- Treated with standard bicarbonate HD for at least the preceding 6 months
Exclusion Criteria:
- Pregnant women or nursing mothers
- Known hypersensitivity to iodine, eggs, albumin or any other component of the Volumex
injection kit
- Current enrollment in another investigational treatment protocol for dialysis
- Kidney transplantation
- Malignancy requiring chemotherapy
- Unmeasurable blood pressure with a sphygmomanometer
- Active hematological disease
- Active gastrointestinal bleeding
- Severe malnutrition (predialysis serum albumin <2.6 g/dL)
- Persistent condition of intradialytic blood pressure instability (hypotensive
episodes in >80% of regular dialysis sessions) within the previous one month period
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