Phase II Study of TAK228 in Relapsed Lymphoma

Study Drug Administration:

If you are found to be eligible for this study, you will begin taking capsules of TAK-228 in
28-day cycles. You will take the drug 1 time every day at about the same time. You should
take the drug with about a cup (8 ounces) of water after eating a light meal. You should fast
for 2 hours before and 1 hour after each dose.

If you vomit or have other digestive side effects that prevent you from taking a dose, that
dose should be skipped. If you vomit up a dose, that dose should not be retaken. In both
cases, wait until the next day to take another dose. In no case should you double or repeat a
dose. You should record any vomiting in the dose diary the study staff provides you with.

Study Visits:

Within 3 days before you start taking TAK-228, blood (about 2 teaspoons) will be drawn for
biomarker testing. Biomarkers are found in the blood/tissue and may be related to your
reaction to the study drug.

On Day 1 of each cycle:

- You will have a physical exam.

- Blood (about 2-3 tablespoons) will be drawn for routine tests. You must fast for 4 hours
before this blood draw. Some of these draws will be used for a diabetes test. If you can
become pregnant, part of this sample will be used for a pregnancy test.

- Blood (about 2 teaspoons) will be drawn for biomarker testing (Cycles 1 and 2 only).

- You will have an EKG (within 3 days of each cycle after Cycle 1).

On Days 8 and 22 of Cycle 1, you will have a physical exam.

On Day 15 of Cycle 1:

- You will have a physical exam

- Blood (about 2-3 tablespoons) will be drawn for routine tests.

Within 5 days before Day 1 of Cycle 3, then every even-numbered cycle after that (Cycles 4,
6, 8, and so on), you will have CT scans, chest x-rays, and a bone marrow biopsy/aspiration
to check the status of the disease.

If the study doctor thinks it is in your best interest, you will have PET/CT scans every 2
cycles to check the status of the disease.

Blood Sugar Testing:

You will be given a glucometer to check your pre-dose blood sugar levels at home every day.
The study staff will teach you how to use the glucometer and what an abnormal reading looks
like. You must tell the study staff right away if you have any abnormal readings. The
frequency of in-home fasting glucose testing may be reduced to once weekly if the doctor
thinks it is needed.

Length of Study:

You may continue to receive the study drug for up to 12 cycles. You will no longer be able to
take the drug if the disease gets worse, if intolerable side effects occur, or if you are
unable to follow study directions.

Your participation in this study will be over after the follow-up phone calls have finished.

End-of-Treatment Visits:

About 1 week after you stop taking the study drug:

- You will have a physical exam

- Blood (about 2-3 tablespoons) will be drawn for routine tests and to test for diabetes.
This will include a pregnancy test if you are able to become pregnant.

- You will have an EKG.

About 2 weeks after you stop taking the study drug, you will have CT scans and chest x-rays
to check the status of the disease. If the study doctor thinks it is needed, you will also
have a bone marrow biopsy/aspiration to check the status of the disease.

Within 2 weeks after you stop taking the study drug, blood (about 2 teaspoons) will be drawn
for biomarker testing.

This is an investigational study. TAK-228 is not FDA approved or commercially available. It
is currently being used for research purposes only. The study doctor can describe how the
study drug is designed to work.

Up to 75 participants will be enrolled in this study. All will take part at MD Anderson.

Inclusion Criteria:

1. Each patient must meet all of the following inclusion criteria to be enrolled in the
study: 1. Male or female patients 18 years or older.

2. Voluntary written consent must be given before performance of any study related
procedure not part of standard medical care, with the understanding that consent may
be withdrawn by the patient at any time without prejudice to future medical care.

3. Female patients who: are postmenopausal for at least 1 year before the screening
visit, OR are surgically sterile, OR if they are of childbearing potential, agree to
practice 1 effective methods of contraception and one additional effective (barrier)
method, at the same time, from the time of signing the informed consent through 90
days (or longer, as mandated bu local labeling [eg,USPI, SmPC, etc;]) after the last
dose of study drug, or agree to practice true abstinence, when this is in line with
the preferred and usual lifestyle of the patient (Periodic abstinence [e.g, calendar,
ovulation, symptothermal, postovulation methods] and withdrawal,spermicides only, ad
lactational amenorrhea are not acceptable methods of contraception.Female and male
condoms should not be used together.

4. Male patients, even if surgically sterilized (ie, status post-vasectomy), who: agree
to practice highly effective barrier contraception during the entire study treatment
period and through 120 days after the last dose of study drug, or agree to practice
true abstinence, when this is in line with the preferred and usual lifestyle of the
patient (Periodic abstinence [e.g, calendar, ovulation, symptothermal, postovulation
methods for the female partner] and withdrawal, spermicides only, ad lactational
amenorrhea are not acceptable methods of contraception. Female and male condoms should
not be used together; Agree not to donate sperm during the course of this study or 120
days after receiving their last dose of study drug

5. Patients must have a diagnosis of prior treated diffuse large b-cell lymphoma, mantle
cell lymphoma, transformed lymphoma, follicular lymphoma (any grade), small
lymphocytic lymphoma, marginal zone lymphoma, or Hodgkin lymphoma with at least 2
lines of therapy without a curative treatment options.

6. Eastern Cooperative Oncology Group (ECOG) performance status and/or other performance
status
7. Adequate organ function, as specified below, within 3 weeks before the first dose of
study drug: a) Bone marrow reserve consistent with: absolute neutrophil count (ANC)
>/=1.5 x 10^9/L; platelet count >/=100 x 10^9/L; hemoglobin >/=9 g/dL without
transfusion within 1 week preceding study drug administration; b) Hepatic: total
bilirubin < /=1.5 x upper limit of normal (ULN), transaminases (aspartate
aminotransferase-AST and alanine aminotransferase ALT) liver metastases are present); c) Renal: creatinine clearance >/= 50 mL/min based
either on Cockcroft-Gault estimate or based on urine collection (12 or 24 hour); d)
Metabolic: fasting serum glucose ( mg/dL;

8. Ability to swallow oral medications;

9. Measurable disease, defined as >/=1.5 cm on imaging assessment.

Exclusion Criteria:

1. Eligible for therapy for the lymphoid malignancy which has a high likelihood of a
curative result in the opinion of the investigator.

2. Female patients who are both lactating and breastfeeding or have a positive serum
pregnancy test during the screening period

3. Any serious medical or psychiatric illness that could, in the investigator's opinion,
potentially interfere with the completion of treatment according to this protocol

4. Concurrent malignancies except basal or squamous cell carcinoma of the skin, or
cervical carcinoma in situ treated with curative intent. Any cancer from which the
patient has been disease free for at least 2 years is permissible.

5. Treatment with any investigational products within 14 days before the first dose of
study drug

6. Failed to recover to baseline or stable grade 1 from the reversible effects of prior
anticancer therapies with the exception of alopecia.

7. Manifestations of malabsorption due to prior gastrointestinal (GI) surgery, GI
disease, or for an unknown reason that may alter the absorption of TAK228; such as
significant chronic diarrhea. In addition, patients with enteric stomata are also
excluded.

8. Poorly controlled diabetes mellitus defined as HbA1c > 7%; subjects with a history of
transient glucose intolerance due to corticosteroid administration are allowed in this
study if all other inclusion/exclusion criteria are met;

9. History of any of the following within the last 6 months prior to study entry:
ischemic myocardial event, including angina requiring therapy and artery
revascularization procedures; Ischemic cerebrovascular event, including TIA and artery
revascularization procedures; Requirement for inotropic support (excluding digoxin) or
serious (uncontrolled) cardiac arrhythmia (including atrial flutter/fibrillation,
ventricular fibrillation or ventricular tachycardia); Placement of a pacemaker for
control of rhythm; New York Heart Association (NYHA) Class III or IV heart failure;
Pulmonary embolism.

10. History of any of the following within the last 6 months prior to study entry:
Requirement of inotropic support; Serious uncontrolled cardiac arrhythmia (including
atrial flutter/fibrillation, ventricular fibrillation or ventricular tachycardia);
Placement of a pacemaker for control of rhythm

11. Significant active cardiovascular or pulmonary disease at the time of study entry,
including: uncontrolled high blood pressure (i.e., systolic blood pressure >180 mm Hg,
diastolic blood pressure > 95 mm Hg) Use of anti-hypertensive agents to control
hypertension before cycle 1 day 1 is allowed; Pulmonary hypertension; Uncontrolled
asthma or O2 saturation < 90% by ABG (Arterial Blood Gas) analysis or pulse oximetry
on room air; Significant valvular disease; severe regurgitation or stenosis by imaging
independent of symptom control with medical intervention, or history of valve
replacement; medically significant (symptomatic) bradycardia; History of arrhythmia
requiring an implantable cardiac defibrillator; Baseline prolongation of the
rate-corrected QT interval (QTc) (e.g., repeated demonstration of QTc interval > 480
milliseconds, or history of congenital long QT syndrome, or torsades de pointes).

12. Treatment with strong inhibitors and/or inducers of cytochrome P450 (CYP) 3A4, CYP2C9
or CYP2C19 within 1 week preceding the first dose of study drug.

13. Patients receiving systemic corticosteroids (either IV or oral steroids, excluding
inhalers or low-dose hormone replacement therapy as defined no greater than 20mg of
prednisone daily) within 1 week before administration of the first dose of study drug.

14. Other clinically significant co-morbidities, such as uncontrolled pulmonary disease,
active central nervous system disease, active infection, or any other condition that
could compromise participation of the patient in the study.

15. Central nervous system (CNS) lymphoma.

16. Known human immunodeficiency virus infection.

17. Known hepatitis B surface antigen-positive, or known or suspected active hepatitis C
infection.

18. Diagnosed or treated for another malignancy within 2 years before administration of
the first dose of study drug, or previously diagnosed with another malignancy and have
any evidence of residual disease. Patients with nonmelanoma skin cancer or carcinoma
in situ of any type are not excluded if they have undergone complete resection

19. Daily or chronic use of a proton pump inhibitor (PPI) and/or having taken a PPI within
7 days before receiving the first dose of study drug