Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism

Inclusion Criteria:

- Adult male subject aged 18 to 65 years inclusive

- BMI > 30 kg/m2 and < 50 kg/m2

- Serum total testosterone concentration below the normal range

- LH levels below the upper limit of normal

- Oestradiol levels within or above the normal range of approved assay

- At least two symptoms of androgen deficiency present for at least 2 months prior to
the first Screening Visit, with at least one of these being a sexual dysfunction

Exclusion Criteria:

- Evidence of clinically significant endocrinopathy at screening that may interfere with
the study assessments

- Other types of hypogonadotropic hypogonadism or primary hypogonadism

- Any other pituitary or hypothalamic disease