Atomoxetine for Treating Marijuana-Abusing Adolescents Who Have Attention Deficit Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder (ADHD) is common among adolescents seeking treatment
for marijuana dependence. Therefore, it is important to develop treatments targeting
adolescents diagnosed with both ADHD and marijuana dependence. Atomoxetine is currently used
to treat individuals diagnosed with ADHD. The purpose of this study is to determine the
feasibility of administering atomoxetine in a therapeutic setting to adolescents who abuse
marijuana and have ADHD. In addition, this study will assess whether atomoxetine reduces ADHD
symptoms. Finally, this study will determine whether atomoxetine improves treatment retention
and progress in adolescents with ADHD and marijuana dependence.

Participants in this double-blind study will be randomly assigned to receive either
atomoxetine or placebo. Study visits will occur 2 times each week for the duration of the
12-week trial. At each study visit, vital signs and medication side effects will be assessed.
In addition, psychiatric ratings measurements will be evaluated. Participants will also
complete self reports in order to track ADHD-related symptoms. Starting at the Week 2 study
visit, all participants will receive psychotherapy sessions. This will involve
cognitive-behavioral therapy/relapse prevention treatment that has been designed specifically
for ADHD adolescents. The aim of the cognitive skills training will be to assist the
participants in developing the skills necessary to manage their drug use as well as the
symptoms they experience related to ADHD. At Month 6, a follow-up visit will occur, at which
time participants urine toxicology tests will be completed to determine if participants have
been using marijuana or any other substances of abuse. In addition, at the Month 6 follow-up
visit, participants will complete psychiatric ratings, self reports, and will meet with a
physician to assess ADHD-related symptoms.

Inclusion Criteria:

- Meets DSM-IV criteria for marijuana dependence and reports that marijuana is their
primary drug of abuse

- Meets DSM-IV criteria for ADHD, as determined by the CAADID

- Females will be included if not pregnant or breastfeeding, and agree to use an
adequate method of contraception for the duration of the study

Exclusion Criteria:

- Meets DSM-IV criteria for schizophrenia, schizoaffective illness, psychotic disorder
other than transient psychosis due to drug abuse, current major depression, bipolar
illness, or psychiatric disorders (individuals with substance-induced mood disorder
with depressive features as well as substance induced anxiety disorder will not be
excluded from the study)

- Medically unstable (based on laboratory tests, an electrocardiogram, medical history,
and physical examination) such that study participation would be hazardous; examples
include uncontrolled high blood pressure and faster than normal heart rate (systolic
blood pressure greater than 130, diastolic blood pressure greater than 80, or a
resting heart rate greater than 90) or diabetes

- History of seizures

- Current suicidal risk

- Pregnant or breastfeeding

- Physiologically dependent on any other drugs (excluding nicotine) that requires a
medical intervention

- Known sensitivity to atomoxetine

- Prior treatment failure with atomoxetine

- Currently receiving effective treatment with atomoxetine

- Coronary vascular disease, as indicated by a history or suspected by an abnormal ECG
or history of cardiac symptoms

- Currently taking a psychotropic medication

- Currently taking cough medicine (e.g., dextromethorphan) or albuterol

- Currently taking or history of taking monoamine oxidase inhibitors (MAOIs) within 2
weeks prior to enrollment

- Narrow angle glaucoma

- Hepatitis

- Adolescents who are prisoners as defined by OHRP regulations, namely directly
court-mandated adolescents (as opposed to probation or parole-mandated clients, as
well as voluntary clients, who will not be excluded)