Immune Suppression and Ventilator Associated Pneumonias
| Status: | Completed |
|---|---|
| Conditions: | Pneumonia, Hospital |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | February 2010 |
| End Date: | November 2012 |
Patients in the ICU are already predisposed to nosocomial infections, which are both costly
and potentially life threatening, and it appears that the immune paralysis of sepsis may put
these patients at greater risk for secondary infections, though this has not been proven
conclusively. One measure of this sepsis-induced immune suppression is monocyte
deactivation. The investigators hypothesize that, as a cornerstone of the monocytic innate
immune response to infection, the inflammasome is critical to monocyte function during
sepsis.
and potentially life threatening, and it appears that the immune paralysis of sepsis may put
these patients at greater risk for secondary infections, though this has not been proven
conclusively. One measure of this sepsis-induced immune suppression is monocyte
deactivation. The investigators hypothesize that, as a cornerstone of the monocytic innate
immune response to infection, the inflammasome is critical to monocyte function during
sepsis.
Sepsis is a systemic inflammatory response to a severe infection. Despite the high incidence
and societal costs of sepsis, the mechanism by which it kills remains unclear. The
pathophysiology of sepsis is not completely understood, but many investigators now believe
that sepsis induces a prolonged state of immune suppression. This study will attempt to
quantify the degree of immune suppression during the first 5 days of sepsis by measuring the
immune function of peripheral blood monocytes and the inflammasome constituent proteins in
peripheral blood monocytes and alveolar macrophages.
and societal costs of sepsis, the mechanism by which it kills remains unclear. The
pathophysiology of sepsis is not completely understood, but many investigators now believe
that sepsis induces a prolonged state of immune suppression. This study will attempt to
quantify the degree of immune suppression during the first 5 days of sepsis by measuring the
immune function of peripheral blood monocytes and the inflammasome constituent proteins in
peripheral blood monocytes and alveolar macrophages.
Inclusion Criteria:
1. ≥ 18 years.
2. Have consensus criteria for sepsis (infection plus two of four systemic inflammatory
response syndrome [SIRS] signs [tachycardia, tachypnea, fever or hypothermia,
leukocytosis or leukopenia]) and a known or suspected infection for SEPTIC arm.
- Patients without criteria for sepsis will be eligible for CONTROL arm. Patient
must consent to have blood drawn within 24 hours of initiation of mechanical
ventilation (for CONTROL arm) and 24 hours of new episode of sepsis to be
eligible (for SEPTIC arm).
Exclusion Criteria:
1. Consent not available or declined
2. Prisoner
3. Died before blood collected
4. Onset of sepsis more than 24 hours prior to transfer to OSUMC,mechanical ventilation
greater than 24 hours
5. Anticipation of less than 24 hours of mechanical ventilation by primary team
6. Women who are pregnant.
We found this trial at
1
site
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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