Study to Investigate Benefits of Weight Loss in Young Adults and Adolescents
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 16 - 32 |
| Updated: | 1/19/2018 |
| Start Date: | May 2011 |
| End Date: | August 2018 |
Study to Investigate Benefits of Weight Loss in Yound Adults and Adolescents
The purpose of this study is to investigate the changes in subcutaneous adipocyte size,
number and gene expression after weight loss and to assess whether those changes contribute
to decreases in ectopic fat accumulation and insulin resistance in women between ages of
16-32.
number and gene expression after weight loss and to assess whether those changes contribute
to decreases in ectopic fat accumulation and insulin resistance in women between ages of
16-32.
There are no studies in young women that have prospectively studied changes in fat cell size,
gene expression and insulin sensitivity during the transition from overweight/obese to normal
weight. Our preliminary data suggest that the presence of ectopic fat accumulation and
insulin resistance in obese children could be considered an "early phase" in the development
of T2DM. We hypothesize that a 10% weight loss will restore/improve insulin sensitivity.
Furthermore, we speculate that the decrease in subcutaneous fat mass after weight loss is due
to a decrease in mean adipocyte cell size, but not cell number.
gene expression and insulin sensitivity during the transition from overweight/obese to normal
weight. Our preliminary data suggest that the presence of ectopic fat accumulation and
insulin resistance in obese children could be considered an "early phase" in the development
of T2DM. We hypothesize that a 10% weight loss will restore/improve insulin sensitivity.
Furthermore, we speculate that the decrease in subcutaneous fat mass after weight loss is due
to a decrease in mean adipocyte cell size, but not cell number.
Inclusion Criteria:
- Women ages 16-32
Exclusion Criteria:
- They will not be on any medications that are known to alter glucose or insulin
metabolism, such as oral steroids, or certain psychiatric medications, such as Xeleca,
Lithium and Paxil. Patients on diuretics will be excluded.
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