Genetic Susceptibility to Oncogenic Viruses
| Status: | Completed |
|---|---|
| Conditions: | Liver Cancer, Cancer, Other Indications, HIV / AIDS |
| Therapuetic Areas: | Immunology / Infectious Diseases, Oncology, Other |
| Healthy: | No |
| Age Range: | 18 - 100 |
| Updated: | 4/6/2019 |
| Start Date: | June 1, 1998 |
An NCI goal is to identify every human gene that predisposes people to cancer. Recent studies
of HIV-1 indicate that genetic polymorphisms can affect susceptibility to viral infections
and that such alleles may be racially restricted, a range of racial and ethnic groups should
be included in such studies. We propose to examine genetic determinants of infection with
hepatitis B virus (HBV) and hepatitis C virus (HCV) in an ethnically diverse population of
injection drug users (IDUs). HBV and HCV are important causes of hepatocellular carcinoma,
but little is known about genetic factors that alter susceptibility to these infections.
Subjects will be recruited in diverse inner-city neighborhoods as part of the University of
California, San Francisco's Urban Health Study. Since 1986, this study has successfully
recruited and evaluated IDUs from street-based settings. About half of the participants are
African-American, one-third are white, 10% are Latino, and the remainder are Asian or Native
American. The mean duration of drug use exceeds 20 years. About 80% of subjects have evidence
of HBV infection and a similar prevalence of HCV infections is anticipated. We will enroll
about 1500 subjects over a 13 month period. Archived, unlinked serum specimens may be
obtained from previous enrollees to increase the sample size, as needed. Highly
exposed-uninfected subjects will be ascertained on the basis of the serologic testing for
each virus, as well as the duration and frequency of injection drug use. These highly
exposed-uninfected subjects will be compared to infected subjects with regard to their
frequency of genetic polymorphisms (chemokines, chemokine receptors, human leukocyte
antigens, and others), in collaboration with scientists from NCI's Laboratory of Genomic
Diversity.
of HIV-1 indicate that genetic polymorphisms can affect susceptibility to viral infections
and that such alleles may be racially restricted, a range of racial and ethnic groups should
be included in such studies. We propose to examine genetic determinants of infection with
hepatitis B virus (HBV) and hepatitis C virus (HCV) in an ethnically diverse population of
injection drug users (IDUs). HBV and HCV are important causes of hepatocellular carcinoma,
but little is known about genetic factors that alter susceptibility to these infections.
Subjects will be recruited in diverse inner-city neighborhoods as part of the University of
California, San Francisco's Urban Health Study. Since 1986, this study has successfully
recruited and evaluated IDUs from street-based settings. About half of the participants are
African-American, one-third are white, 10% are Latino, and the remainder are Asian or Native
American. The mean duration of drug use exceeds 20 years. About 80% of subjects have evidence
of HBV infection and a similar prevalence of HCV infections is anticipated. We will enroll
about 1500 subjects over a 13 month period. Archived, unlinked serum specimens may be
obtained from previous enrollees to increase the sample size, as needed. Highly
exposed-uninfected subjects will be ascertained on the basis of the serologic testing for
each virus, as well as the duration and frequency of injection drug use. These highly
exposed-uninfected subjects will be compared to infected subjects with regard to their
frequency of genetic polymorphisms (chemokines, chemokine receptors, human leukocyte
antigens, and others), in collaboration with scientists from NCI's Laboratory of Genomic
Diversity.
An NCI goal is to identify every human gene that predisposes people to cancer. Recent studies
of HIV -1 indicate that genetic polymorphisms can affect susceptibility to viral infections
and that such alleles may be detected in studies of small numbers of highly
exposed-uninfected subjects. Because such alleles may be racially restricted, a range of
racial and ethnic groups should be included in such studies. We propose to examine genetic
determinants of infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in an
ethnically diverse population of injection drug users (lDUs). HBV and HCV are important
causes of hepatocellular carcinoma, but little is known about genetic factors that alter
susceptibility to these infections. Subjects will be recruited in diverse inner-city
neighborhoods as part of the University of California, San Francisco's Urban Health Study.
Since 1986, this study has successfully recruited and evaluated IDUs from street-based
settings. About half of the participants are African-American, one-third are white, 10% are
Latino, and the remainder are Asian or Native American. The mean duration of drug use exceeds
20 years. About 80% of subjects have evidence of HBV infection and a similar prevalence of
HCV infection is anticipated. We will enroll about 1500 subjects over a 13 month period.
Archived, unlinked serum specimens may obtained from previous enrollees to increase the
sample size, as needed. Highly exposed-uninfected subjects will be ascertained on the basis
of the serologic testing for each virus, as well as the duration and frequency of injection
drug use. These highly exposed-uninfected subjects will be compared to infected subjects with
regard to their frequency of genetic polymorphisms (chemokines, chemokine receptors, human
leukocyte antigens, and others), in collaboration with scientists from NCI's Laboratory of
Genomic Diversity.
of HIV -1 indicate that genetic polymorphisms can affect susceptibility to viral infections
and that such alleles may be detected in studies of small numbers of highly
exposed-uninfected subjects. Because such alleles may be racially restricted, a range of
racial and ethnic groups should be included in such studies. We propose to examine genetic
determinants of infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in an
ethnically diverse population of injection drug users (lDUs). HBV and HCV are important
causes of hepatocellular carcinoma, but little is known about genetic factors that alter
susceptibility to these infections. Subjects will be recruited in diverse inner-city
neighborhoods as part of the University of California, San Francisco's Urban Health Study.
Since 1986, this study has successfully recruited and evaluated IDUs from street-based
settings. About half of the participants are African-American, one-third are white, 10% are
Latino, and the remainder are Asian or Native American. The mean duration of drug use exceeds
20 years. About 80% of subjects have evidence of HBV infection and a similar prevalence of
HCV infection is anticipated. We will enroll about 1500 subjects over a 13 month period.
Archived, unlinked serum specimens may obtained from previous enrollees to increase the
sample size, as needed. Highly exposed-uninfected subjects will be ascertained on the basis
of the serologic testing for each virus, as well as the duration and frequency of injection
drug use. These highly exposed-uninfected subjects will be compared to infected subjects with
regard to their frequency of genetic polymorphisms (chemokines, chemokine receptors, human
leukocyte antigens, and others), in collaboration with scientists from NCI's Laboratory of
Genomic Diversity.
- INCLUSION CRITERIA:
18 years or older
Active IDU as verified by self-report and physical examination for visible signs consistent
with multiple drug injection.
EXCLUSION CRITERIA:
Subject unable to give informed consent.
We found this trial at
1
site
Click here to add this to my saved trials
