Remote Ischemic Limb Preconditioning In Healthy Volunteers
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology, Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 9/30/2018 |
| Start Date: | October 2015 |
| End Date: | July 2019 |
| Contact: | Sebastian Koch, MD |
| Email: | skoch@med.miami.edu |
| Phone: | 305-243-6732 |
Does Remote Ischemic Limb Preconditioning Improve Cerebral Vasomotor Reactivity in Healthy Volunteers?
The investigators would like to determine if remote ischemic leg preconditioning in healthy
volunteers improves cerebral vasomotor reactivity as measured by breath holding and
transcranial doppler vasomotor reactivity.
volunteers improves cerebral vasomotor reactivity as measured by breath holding and
transcranial doppler vasomotor reactivity.
This study is to determine if remote ischemic leg preconditioning improves short and long
term cerebral vasomotor reactivity in healthy volunteers as measured by breath holding and
transcranial doppler vasomotor reactivity. Previous studies on brachial vasomotor reactivity
have shown a beneficial effect of remote ischemic preconditioning. It remains uncertain if a
similar beneficial effect can be reproduced with cerebral vasomotor testing. Many biological
mechanisms and effector pathways triggered by preconditioning have demonstrated endothelial
protection and beneficial vascular effects.
term cerebral vasomotor reactivity in healthy volunteers as measured by breath holding and
transcranial doppler vasomotor reactivity. Previous studies on brachial vasomotor reactivity
have shown a beneficial effect of remote ischemic preconditioning. It remains uncertain if a
similar beneficial effect can be reproduced with cerebral vasomotor testing. Many biological
mechanisms and effector pathways triggered by preconditioning have demonstrated endothelial
protection and beneficial vascular effects.
Inclusion Criteria:
- Healthy volunteers
Exclusion Criteria:
- Presence of chronic medical conditions such as diabetes, hypertension, cardiac disease
etc.
- Any prescribed medication
- Pregnancy [by history and last menstrual period]
- Any leg injury that would, in the opinion of the investigator, affect preconditioning
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University of Miami A private research university with more than 15,000 students from around the...
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