Effectiveness of Gabapentin When Used With Naltrexone to Treat Alcohol Dependence Compared to Placebo and Naltrexone Alone
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 6/9/2018 |
| Start Date: | January 2003 |
| End Date: | June 2009 |
Gabapentin as an Adjunct to Naltrexone for Alcoholism
The purpose of this study is to determine whether, after a period of abstinence, adding 6
weeks of gabapentin (a medication approved to treat seizures) to a standard 16-week
naltrexone (an opiate blocking agent approved for the treatment of alcohol dependence)
treatment protocol is helpful in decreasing relapse to drinking compared to naltrexone alone
or placebo. All participants will receive alcohol counseling.
weeks of gabapentin (a medication approved to treat seizures) to a standard 16-week
naltrexone (an opiate blocking agent approved for the treatment of alcohol dependence)
treatment protocol is helpful in decreasing relapse to drinking compared to naltrexone alone
or placebo. All participants will receive alcohol counseling.
Subjects will enter the trial after maintaining 4 days of abstinence. During this period
multiple assessments will be collected. After entering the double blind treatment portion of
the study, they will be evaluated weekly for the first month, then bi-weekly until week 12
and again at week 16. There will be two follow-up visits at weeks 28 and 40. Urinary
riboflavin and pill counts will be utilized to determine compliance with the medication
regime.
Comparison(s): Naltrexone (50 mg/day) alone for 16-weeks; naltrexone (50 mg/day) for 16-weeks
plus gabapentin (up to 1200 mg/day in divided doses) for the first 6 weeks, or inactive
placebos. All subjects will receive up to 20 sessions of individual alcohol counseling.
multiple assessments will be collected. After entering the double blind treatment portion of
the study, they will be evaluated weekly for the first month, then bi-weekly until week 12
and again at week 16. There will be two follow-up visits at weeks 28 and 40. Urinary
riboflavin and pill counts will be utilized to determine compliance with the medication
regime.
Comparison(s): Naltrexone (50 mg/day) alone for 16-weeks; naltrexone (50 mg/day) for 16-weeks
plus gabapentin (up to 1200 mg/day in divided doses) for the first 6 weeks, or inactive
placebos. All subjects will receive up to 20 sessions of individual alcohol counseling.
Inclusion Criteria:
- Meet criteria for primary alcohol dependence including loss of control of drinking
- No more than one previous inpatient medical detoxification
- Consumes on average 5 standard drinks for men and 4 standard drinks for women
- Able to maintain sobriety for 4 days (with or without detox medications).
- Able to read and understand questionnaires and Informed Consent
- Lives within 50 miles of the study site
Exclusion Criteria:
- Currently meets DSM-IV criteria for any other psychoactive substance dependency
disorder except nicotine dependence
- Ever abused opiates
- Any psychoactive substance abuse, except marijuana and nicotine within the last 30
days as evidenced by subject report, collateral report, or urine drug screen.
- Meets DSM-IV criteria for current Axis I disorder of major depression, panic disorder,
obsessive-compulsive disorder, post-traumatic stress syndrome, bipolar affective
disorder, dissociative disorder or eating disorder, schizophrenia, or any other
psychotic disorder or organic mental disorder.
- Has current suicidal or homicidal ideation
- Need for maintenance or acute treatment with any psychoactive medication including
antiseizure medications.
- Current use of disulfiram.
- Clinically significant medical problems, such as cardiovascular, renal, GI or
endocrine problem that would impair participation or limit medication ingestion.
- Hepatocellular disease indicated by elevations of SGPT (ALT) and SGOT (AST) of at
least 3.0 times normal at screening and/or after 5 days of abstinence.
- Sexually active females of child bearing potential who are pregnant (by urine HCG),
nursing or who are not using a reliable form of birth control.
- Has current charges pending for a violent crime (not including DUI related offenses).
- Does not have a stable living situation and a reliable source of collateral reporting.
- Has taken an opiate antagonist drug in the last month.
- Has taken gabapentin in the last month or has experienced adverse effects from it at
any time in the past.
We found this trial at
1
site
Charleston, South Carolina 29425
Click here to add this to my saved trials
