Double-blind, Randomized Study Evaluating the Efficacy and Safety of Brivaracetam in Adults With Partial Onset Seizures

Inclusion Criteria:

- Subjects were 16 to 70 years, both inclusive. Subjects under 18 years of age were only
included where legally permitted and ethically accepted

- Subjects with well-characterized focal epilepsy or epileptic syndrome according to the
International League Against Epilepsy (ILAE) classification

- Subjects had a history of partial onset seizures (POS) whether or not secondarily
generalized (Type I seizures according to the ILAE classification)

- Subjects had at least 2 POS whether or not secondarily generalized per month during
the 3 months preceding Visit 1 (V1)

- Subjects had at least 8 POS whether or not secondarily generalized during the 8-Week
Baseline Period

- Subjects were uncontrolled while treated by 1 to 2 permitted concomitant antiepileptic
drug(s) (AEDs). Vagal nerve stimulation (VNS) was allowed and was not counted as a
concomitant AED

Exclusion Criteria:

- History or presence of seizures occurring only in clusters (too frequently or
indistinctly separated to be reliably counted) before Visit 3

- History or presence of status epilepticus during the year preceding Visit 1 or during
Baseline