Immunopathogenesis of Chlamydia

Sexually transmitted Chlamydia trachomatis infections are a widespread public health concern
due to their prevalence and potentially devastating reproductive consequences, including
pelvic inflammatory disease, infertility, and ectopic pregnancy. The goal of this study is
to evaluate the risk factors for adverse outcomes following genital tract infection with
Chlamydia trachomatis and to evaluate whether or not the presence of C. trachomatis in the
rectum act as a reservoir for infection. Our target population will be adolescent females
age 11-21 evaluated at the ACH Adolescent Center who are undergoing pelvic examinations or
urine screening for sexually transmitted infections (STIs). Laboratory specimens obtained
will include cervical and rectal swabs, urine and blood specimens, as well as, chart review
and comprehensive subject interviews in the initial data collection with follow-up
evaluations at 3, 6, 12, 24 and 36 months for qualifying subjects

Inclusion Criteria:

- Female

- 11 to 21 years of age at the time of enrollment

- Positive for Chlamydia infections by urine or cervical PCR

- 5th Chlamydia-negative subject who fits all other inclusion criteria

- Negative pregnancy test

- Written informed consent provided

- Signed a HIPAA authorization form

- Willingness to comply with all the requirements of the protocol

Exclusion Criteria:

- Positive pregnancy test

- Negative for Chlamydia, unless 5th negative subject to be in the control group

- Any condition that in the opinion of the investigator would interfere with the
ability of the potential subject to complete the study or would result in significant
risk to the subject