A Double-blind, Randomized Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset Seizures



Status:Terminated
Conditions:Neurology, Epilepsy
Therapuetic Areas:Neurology, Other
Healthy:No
Age Range:16 - 75
Updated:7/13/2018
Start Date:August 2008
End Date:February 2010

Use our guide to learn which trials are right for you!

An International, Double-blind, Randomized, Multi-center, Parallel Group, Historical-control Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset Seizures With or Without Secondary Generalization

Antiepileptic drugs (AEDs) are the main treatment for epilepsy; however, only a limited
number of AEDs are approved for use as monotherapy. The objective of this study is to
evaluate the efficacy of Brivaracetam (BRV) in the conversion of partial onset seizure
patients from combination treatment to monotherapy


Inclusion Criteria:

- Subjects from 16 to 75 years, both inclusive

- Well-characterized focal epilepsy or epileptic syndrome

- Subjects having at least 2 but not exceeding 40 partial onset seizures, whether or not
secondarily generalized per 4 weeks during the 8-week Baseline Period

- Subjects on a stable dose of at least 1 but no more than 2 concomitant Antiepileptic
Drugs (AEDs) with the second AED ≤ 50 % of the minimum recommended maintenance dose

Exclusion Criteria:

- Seizure type IA non-motor as only seizure type

- History or presence of seizures occurring too frequently or indistinctly separated to
be reliably counted during the 6 months preceding Visit 1 or during Baseline

- Other serious uncontrolled disease
We found this trial at
27
sites
493
mi
from 43215
Macon, GA
Click here to add this to my saved trials
1069
mi
from 43215
Austin, TX
Click here to add this to my saved trials
482
mi
from 43215
Bronx, NY
Click here to add this to my saved trials
638
mi
from 43215
Burlington, MA
Click here to add this to my saved trials
Charleston, West Virginia 25304
138
mi
from 43215
Charleston, WV
Click here to add this to my saved trials
9456
mi
from 43215
Chatswood,
Click here to add this to my saved trials
441
mi
from 43215
Conyers, GA
Click here to add this to my saved trials
910
mi
from 43215
Dallas, TX
Click here to add this to my saved trials
303
mi
from 43215
Danville, VA
Click here to add this to my saved trials
1162
mi
from 43215
Denver, CO
Click here to add this to my saved trials
1993
mi
from 43215
Fresno, CA
Click here to add this to my saved trials
501
mi
from 43215
Germantown, TN
Click here to add this to my saved trials
304
mi
from 43215
Hickory, NC
Click here to add this to my saved trials
991
mi
from 43215
Houston, TX
Click here to add this to my saved trials
63
mi
from 43215
Kettering, OH
Click here to add this to my saved trials
1767
mi
from 43215
Las Vegas, NV
Click here to add this to my saved trials
154
mi
from 43215
Lexington, KY
Click here to add this to my saved trials
993
mi
from 43215
Miami, FL
Click here to add this to my saved trials
496
mi
from 43215
Mineola, NY
Click here to add this to my saved trials
481
mi
from 43215
New York, NY
Click here to add this to my saved trials
849
mi
from 43215
Oklahoma City, OK
Click here to add this to my saved trials
792
mi
from 43215
Orlando, FL
Click here to add this to my saved trials
1964
mi
from 43215
Pasadena, CA
Click here to add this to my saved trials
348
mi
from 43215
Peoria, IL
Click here to add this to my saved trials
1662
mi
from 43215
Phoenix, AZ
Click here to add this to my saved trials
458
mi
from 43215
Summit, NJ
Click here to add this to my saved trials
341
mi
from 43215
Waukesha, WI
Click here to add this to my saved trials