A Double-blind, Randomized Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset Seizures



Status:Terminated
Conditions:Neurology, Epilepsy
Therapuetic Areas:Neurology, Other
Healthy:No
Age Range:16 - 75
Updated:7/13/2018
Start Date:August 2008
End Date:February 2010

Use our guide to learn which trials are right for you!

An International, Double-blind, Randomized, Multi-center, Parallel Group, Historical-control Conversion to Monotherapy Study to Evaluate the Efficacy and Safety of Brivaracetam in Subjects (≥ 16 to 75 Years Old) With Partial Onset Seizures With or Without Secondary Generalization

Antiepileptic drugs (AEDs) are the main treatment for epilepsy; however, only a limited
number of AEDs are approved for use as monotherapy. The objective of this study is to
evaluate the efficacy of Brivaracetam (BRV) in the conversion of partial onset seizure
patients from combination treatment to monotherapy


Inclusion Criteria:

- Subjects from 16 to 75 years, both inclusive

- Well-characterized focal epilepsy or epileptic syndrome

- Subjects having at least 2 but not exceeding 40 partial onset seizures, whether or not
secondarily generalized per 4 weeks during the 8-week Baseline Period

- Subjects on a stable dose of at least 1 but no more than 2 concomitant Antiepileptic
Drugs (AEDs) with the second AED ≤ 50 % of the minimum recommended maintenance dose

Exclusion Criteria:

- Seizure type IA non-motor as only seizure type

- History or presence of seizures occurring too frequently or indistinctly separated to
be reliably counted during the 6 months preceding Visit 1 or during Baseline

- Other serious uncontrolled disease
We found this trial at
27
sites
2293
mi
from 98109
Danville, VA
Click here to add this to my saved trials
1775
mi
from 98109
Austin, TX
Click here to add this to my saved trials
2402
mi
from 98109
Bronx, NY
Click here to add this to my saved trials
2474
mi
from 98109
Burlington, MA
Click here to add this to my saved trials
Charleston, West Virginia 25304
2130
mi
from 98109
Charleston, WV
Click here to add this to my saved trials
7746
mi
from 98109
Chatswood,
Click here to add this to my saved trials
2200
mi
from 98109
Conyers, GA
Click here to add this to my saved trials
1682
mi
from 98109
Dallas, TX
Click here to add this to my saved trials
1020
mi
from 98109
Denver, CO
Click here to add this to my saved trials
766
mi
from 98109
Fresno, CA
Click here to add this to my saved trials
1877
mi
from 98109
Germantown, TN
Click here to add this to my saved trials
2238
mi
from 98109
Hickory, NC
Click here to add this to my saved trials
1890
mi
from 98109
Houston, TX
Click here to add this to my saved trials
1963
mi
from 98109
Kettering, OH
Click here to add this to my saved trials
872
mi
from 98109
Las Vegas, NV
Click here to add this to my saved trials
2005
mi
from 98109
Lexington, KY
Click here to add this to my saved trials
2255
mi
from 98109
Macon, GA
Click here to add this to my saved trials
2730
mi
from 98109
Miami, FL
Click here to add this to my saved trials
2417
mi
from 98109
Mineola, NY
Click here to add this to my saved trials
2400
mi
from 98109
New York, NY
Click here to add this to my saved trials
1523
mi
from 98109
Oklahoma City, OK
Click here to add this to my saved trials
2544
mi
from 98109
Orlando, FL
Click here to add this to my saved trials
956
mi
from 98109
Pasadena, CA
Click here to add this to my saved trials
1678
mi
from 98109
Peoria, IL
Click here to add this to my saved trials
1116
mi
from 98109
Phoenix, AZ
Click here to add this to my saved trials
2385
mi
from 98109
Summit, NJ
Click here to add this to my saved trials
1673
mi
from 98109
Waukesha, WI
Click here to add this to my saved trials