Fingerprinting of Impulsivity

Inclusion criteria:

All cohorts:

- Males and females ages 18-50.

Healthy Control cohort:

- Volunteers in generally good Psychiatric and non-Psychiatric medical health

Borderline Personality Disorder (2 cohorts):

- Subjects who meet Diagnostic and Statistical Manual of Mental Disorders-V (DSM-V)
criteria for Borderline Personality Disorder

Binge Eating Disorder cohort:

- Subjects who meet DSM-V criteria for Binge Eating Disorder.

Stimulant Use Disorder cohort:

- Subjects who meet DSM-V criteria for current Stimulant Use Disorder, subtype cocaine,
moderate or severe use

Attention Deficit Hyperactivity Disorder cohort:

- Subjects who meet DSM-V criteria for adult Attention Deficit Hyperactivity Disorder

Exclusion criteria:

General:

- Positive breathalyzer test for alcohol at any study visit

- History of clinically significant neurologic disorders or head trauma with loss of
consciousness greater than 30 minutes

- Clinically significant non-psychiatric medical disorder requiring ongoing treatment as
judged by the investigator.

- Unwillingness or inability to sign a written informed consent form

- Pregnancy as assessed by a urine test for ß-Human Chorionic Gonadotropin (ß-HCG) at
screening visit

- Medical or physical contraindications for participation (see below), based on medical
history interview, as judged by the investigator

- Unwilling to refrain from tobacco use one hour prior to testing until after conclusion
of testing

Healthy Controls:

- Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnoses of Personality
Disorders (based on Structured Clinical Interview for DSM-IV (SCID)-II)

- DSM-5 diagnoses based on the SCID-I (including the eating disorders and Attention
Deficit Hyperactivity Disorder (ADHD) module)

- History of arrest or incarceration

- Positive urine drug screen for cannabis, cocaine, opioids, amphetamine, and
benzodiazepines at any visit

- Current Tobacco Users

Borderline Personality Disorder Subjects:

- DSM-5 diagnoses other than: Tobacco Use Disorder, Major Depressive Disorder (Mild
Subtype), Generalized Anxiety Disorder (in remission), Post-Traumatic Stress Disorder
(in remission), Major Depressive Disorder (Moderate or Severe Subtype, in remission),
or Substance use disorder (Mild subtype, in remission)

- DSM-5 Personality Disorder other than Cluster B Personality disorders.

- Positive urine drug screen for cocaine, opioids, amphetamine, and benzodiazepines at
any visit

- Antipsychotic medication or mood stabilizers taken within the last 30 days or change
in antidepressant medication within the last 30 days.

Binge Eating Disorder Subjects:

- DSM-5 diagnoses other than: Binge Eating Disorder (current bulimia also excluded),
Tobacco Use Disorder, Major Depressive Disorder (in remission), Generalized Anxiety
Disorder (in remission), Post-Traumatic Stress Disorder (in remission), and Substance
Use Disorder (in remission, mild subtype).

- DSM-5 diagnoses of Cluster B Personality disorders.

- Positive urine drug screen for cocaine, opioids, amphetamine, and benzodiazepines at
any visit

Stimulant Use Disorder, Cocaine Subtype Subjects:

- DSM-5 diagnoses other than: Stimulant Use Disorder, Cannabis Use Disorder, Alcohol Use
Disorder (Mild Subtype), and Tobacco Use Disorder, Substance Induced Mood Disorder,
Major Depressive Disorder (in remission), Generalized Anxiety Disorder (in remission),
Post-Traumatic Stress Disorder (in remission).

- DSM-5 diagnoses of Cluster B Personality Disorders.

- Positive urine drug screen for opioids, amphetamine, and benzodiazepines at any visit

ADHD Subjects:

- DSM-5 diagnoses other than ADHD, Substance Induced Mood Disorder, Major Depressive
Disorder (in remission), Generalized Anxiety Disorder (in remission), Post-Traumatic
Stress Disorder (in remission), Substance Use Disorder (mild subtype, in remission).

- DSM-5 diagnoses of Cluster B Personality Disorders.

- Stimulant medication taken the morning of behavioral testing.

- Positive urine drug screen for cannabis, cocaine, opioids, amphetamine,
methamphetamine or benzodiazepines at any visit. Subjects with a valid prescription
for amphetamines for the treatment of ADHD will not be excluded.

- Unable or unwilling to withhold medications prescribed for treatment of ADHD on the
morning of any behavioral testing clinic visit.

- Further exclusion criteria apply