Low Intensity Weight Loss for Young Adults

A 3-arm randomized controlled trial will be conducted, the goal of which is to determine
which group represents the most viable approach to behavioral weight loss treatment with
18-25 year olds. A total of 381 participants,18-25 years of age, with a BMI between 25 and 45
kg/m2 will be randomized to one of three groups: 1) Behavioral Weight Loss (BWL), 2) BWL +
Autonomous Motivation (BWL+Aut) or 3) BWL + Extrinsic Motivation (BWL+Ext). All arms will
receive a 24-week behavioral weight loss intervention, including personalized dietary,
physical activity, and weight loss prescriptions. In addition, all arms will be followed for
a 6 month no treatment follow-up period. Assessments of weight and secondary outcomes will
occur in 0, 3, 6 and 12 months. The investigators will compare treatment effects, across all
3 arms at 6 months, and compare arms on weight loss maintenance at12 months. The
investigators will also examine mediators of treatment outcomes consistent with the
investigators theoretical framework.

Inclusion Criteria:

- Between 18-25 years of age. Body Mass Index (BMI) between 25 and 45 kg/m2. Men and
women will be recruited. All race and ethnic groups will be recruited.

Exclusion Criteria:

- Report an uncontrolled medical condition that may pose a safety issue given the
recommendations for diet and unsupervised physical activity in the current study
(e.g., uncontrolled hypertension). The investigators will refer individuals who have
blood pressure levels >140 / 90 mmHg as part of baseline screening to their physician
and exclude them from this study unless their treating physician determines s/he is a
suitable candidate based on the specifics of the protocol and provides written medical
consent for participation. Participants who report a history of or current treatment
for medical conditions (e.g., hypertension, diabetes) will be asked to obtain MD
consent to participate.

- Other health problems or medications which may influence the ability to walk for
physical activity or be associated with unintentional weight change, including cancer
treatment within the past 5 years or tuberculosis.

- Report a heart condition, chest pain during periods of activity or rest, or loss of
consciousness on the Physical Activity Readiness Questionnaire (PAR-Q), which will be
administered during prescreen. Individuals endorsing joint problems, prescription
medication usage, or other medical conditions that could limit exercise will be
required to obtain written physician consent to participate.

- Report a history of, or current diagnosis of anorexia nervosa or bulimia nervosa, or
any current compensatory behaviors (e.g., vomiting, laxative use, excessive exercise).

- Current symptoms of alcohol or substance dependence.

- Planning to move from the area within the study period.

- Currently pregnant, pregnant within the past 6 months, currently breastfeeding or
planning to become pregnant within the next 12 months.

- Hospitalization for depression or other psychiatric disorder within the past 12
months. History of psychotic disorder or bipolar disorder.

- Another member of the household is a participant or staff member on this study.

- Participation in another research study that may interfere with this study.

- Currently participating in a weight loss program and/or taking weight loss medication
or lost > 5% of body weight during the past 3 months.

- Failure to complete the screening appointments.