Whole Egg Intake and the Mediterranean Diet
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 20 - 75 |
| Updated: | 3/27/2019 |
| Start Date: | April 2016 |
| End Date: | December 2020 |
| Contact: | Matthew Picklo, PhD |
| Email: | matthew.picklo@ars.usda.gov |
| Phone: | 701-795-8380 |
This project will evaluate the daily intake of whole eggs in the Mediterranean Diet (Med
Diet). Cholesterol levels are normally related to cardiovascular disease (CVD) risk. Dietary
fat and the total diet makeup are well known modifiers of CVD risk. The Med Diet has been
shown to decrease blood lipids (fats) and reduce inflammation. Cholesterol intake from eggs
may not be as bad as once thought and, in fact, may help to improve the blood lipid (fat)
levels. This study is being done to test how the addition of eggs to a Med Diet affects blood
lipids and other risk markers for CVD.
Diet). Cholesterol levels are normally related to cardiovascular disease (CVD) risk. Dietary
fat and the total diet makeup are well known modifiers of CVD risk. The Med Diet has been
shown to decrease blood lipids (fats) and reduce inflammation. Cholesterol intake from eggs
may not be as bad as once thought and, in fact, may help to improve the blood lipid (fat)
levels. This study is being done to test how the addition of eggs to a Med Diet affects blood
lipids and other risk markers for CVD.
Elevated serum cholesterol is a major contributor to cardiovascular disease (CVD), which is
responsible for ~1/3 of all deaths in the US. However, about 50% of those who experience
heart attacks have normal cholesterol levels. Cholesterol is carried in lipoproteins (HDL,
LDL, and VLDL) and the amount in circulation is used to evaluate CVD risk. However, the
particle size and density of lipoprotein subfractions may be more predictive for
atherogenesis than their total levels. Dietary fatty acids are well recognized modulators of
lipoproteins, and ultimately CVD risk. Saturated and trans fatty acids have a negative effect
on CVD risk while poly- and monounsaturated fatty acids (PUFA, MUFA) appear to be protective.
The Mediterranean Diet (Med Diet) decreases atherogenic lipoproteins and reduces systemic
inflammation. It is unknown how high cholesterol intake within a Med Diet will affect these
parameters, although recent evidence implies that the fatty acid content of the diet is more
important than the cholesterol content. Therefore, this project will evaluate the daily
inclusion of whole eggs, a high cholesterol food, in the Med Diet on lipid profiles,
lipoprotein particle size and density and biomarkers of systemic inflammation.
responsible for ~1/3 of all deaths in the US. However, about 50% of those who experience
heart attacks have normal cholesterol levels. Cholesterol is carried in lipoproteins (HDL,
LDL, and VLDL) and the amount in circulation is used to evaluate CVD risk. However, the
particle size and density of lipoprotein subfractions may be more predictive for
atherogenesis than their total levels. Dietary fatty acids are well recognized modulators of
lipoproteins, and ultimately CVD risk. Saturated and trans fatty acids have a negative effect
on CVD risk while poly- and monounsaturated fatty acids (PUFA, MUFA) appear to be protective.
The Mediterranean Diet (Med Diet) decreases atherogenic lipoproteins and reduces systemic
inflammation. It is unknown how high cholesterol intake within a Med Diet will affect these
parameters, although recent evidence implies that the fatty acid content of the diet is more
important than the cholesterol content. Therefore, this project will evaluate the daily
inclusion of whole eggs, a high cholesterol food, in the Med Diet on lipid profiles,
lipoprotein particle size and density and biomarkers of systemic inflammation.
Inclusion Criteria:
- Willingness to comply with the demands of the experimental protocol
- Not performing vigorous exercise >2 times per week
- BMI 25-39.9 kg/m2
- Non-smoking
Exclusion Criteria:
- Have an egg allergy
- Have diabetes
- Have high triglyceride levels
- Have uncontrolled high blood pressure
- Use prescription medications or over-the-counter lipid lowering drugs (such as
statins) or anti-inflammatory medications (such as aspirin, ibuprofen or Aleve) on a
regular basis
- Take omega 3 supplements, plant sterols or sterol esters
- Are pregnant or lactating
- Have been diagnosed with an eating disorder
- Inability to give consent
- Unwillingness or inability to consume the treatment diets
We found this trial at
1
site
Grand Forks, North Dakota 58202
Phone: 701-795-8386
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