Tumor-educated Platelets in Venous Thromboembolism
| Status: | Recruiting |
|---|---|
| Conditions: | Cancer, Cardiology, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Oncology |
| Healthy: | No |
| Age Range: | 40 - Any |
| Updated: | 11/16/2017 |
| Start Date: | June 2016 |
| End Date: | March 2019 |
| Contact: | Noémie Kraaijpoel, MD |
| Email: | n.kraaijpoel@amc.nl |
| Phone: | 0031205667050 |
Platelet RNA Profiling to Detect Occult Cancer in Patients With Unprovoked Venous Thromboembolism
Among patients with a first episode of unprovoked venous thromboembolism (VTE), the
contemporary one-year risk of detecting occult cancer is approximately 4% to 7%. Of these
cases, 30% to 60% are missed by routine limited screening for cancer. RNA profiling of
platelets is a promising, highly accurate biomarker for cancer detection, but its clinical
utility in patients with unprovoked VTE is unknown. The objective of the present study is to
evaluate the diagnostic accuracy of platelet RNA profiling in detecting occult cancer in
patients with unprovoked venous thromboembolism. Secondary objectives include evaluation of
other biomarkers for cancer, prediction of bleeding, and prediction of recurrent VTE.
contemporary one-year risk of detecting occult cancer is approximately 4% to 7%. Of these
cases, 30% to 60% are missed by routine limited screening for cancer. RNA profiling of
platelets is a promising, highly accurate biomarker for cancer detection, but its clinical
utility in patients with unprovoked VTE is unknown. The objective of the present study is to
evaluate the diagnostic accuracy of platelet RNA profiling in detecting occult cancer in
patients with unprovoked venous thromboembolism. Secondary objectives include evaluation of
other biomarkers for cancer, prediction of bleeding, and prediction of recurrent VTE.
Inclusion Criteria:
- First episode of objectively confirmed, symptomatic, unprovoked symptomatic pulmonary
embolism and/or distal or proximal deep vein thrombosis of the leg
- Age 40 years or older
- Written informed consent
Exclusion Criteria:
- known malignant disease prior to VTE defined as a cancer diagnosis or cancer treatment
within the past 5 years (of note: suspected but unconfirmed cancer at diagnosis of VTE
is allowed);
- trauma or fracture of the leg, surgical procedures, general anesthesia, or
immobilization greater than 3 days within previous 3 months;
- previous unprovoked venous thromboembolism;
- known hereditary or acquired thrombophilia;
- current pregnancy or puerperium (up to 3 months postpartum);
- current estrogen therapy.
- Greater than 10 days after VTE diagnosis;
- Inability for blood withdrawal at baseline;
- Inability or refusal to provide written informed consent.
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