Persea Americana for Total Health (PATH ) Study
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 25 - 45 |
| Updated: | 4/21/2016 |
| Start Date: | February 2016 |
| End Date: | February 2019 |
| Contact: | Hannah D Holscher, PhD RD |
| Email: | hholsche@illinois.edu |
| Phone: | 217-300-2512 |
Investigating the Effects of Avocado Intake on Metabolism and Cognition: A Systems Approach
The proposed work will investigate the effects of avocados on abdominal obesity and glycemic
control among overweight/obese adults. Further, changes in GI microbiota composition and
cognitive function will be assessed to comprehensively understand systemic benefits of
avocado consumption on gut and brain function. This research study has two aims: 1) To
determine the effects of regular avocado intake on metabolic syndrome risk factors,
specifically, abdominal obesity and glycemic control, among overweight and obese adults; and
2) to investigate the implications of avocado intake on measures of GI microbiota
composition and cognitive function.
control among overweight/obese adults. Further, changes in GI microbiota composition and
cognitive function will be assessed to comprehensively understand systemic benefits of
avocado consumption on gut and brain function. This research study has two aims: 1) To
determine the effects of regular avocado intake on metabolic syndrome risk factors,
specifically, abdominal obesity and glycemic control, among overweight and obese adults; and
2) to investigate the implications of avocado intake on measures of GI microbiota
composition and cognitive function.
Inclusion Criteria:
- Males and females
- Between the ages of 25-45 years at the time of consent
- Body mass index ≥27.5kg/m2
- Normal or corrected-to-normal vision based on the minimal 20/20 standard in order to
complete the cognitive task (below 20/20 vision).
- Ability to drop-off fecal sample within 15 minutes of defecation
Exclusion Criteria:
- Current pregnancy or lactation
- Tobacco use
- Avocado allergy or intolerance
- Food allergies, lactose intolerance
- Latex allergy
- Prior diagnosis of metabolic and gastrointestinal disease (cardiovascular disease and
type 1 or type 2 diabetes, chronic constipation, diarrhea, Crohn's disease, celiac
disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or
duodenal ulcers, hepatitis, HIV, cancer, etc.)
- Prior diagnosis of cognitive or physical disability, including ADHD, severe asthma,
epilepsy, chronic kidney disease, and dependence upon a wheelchair/walking
- Use of any anti-psychotic, anti-depressant, anti-anxiety, or ADD/ADHD medications
- Use of medications that alter normal bowel function and metabolism (e.g., recent
antibiotic use, laxatives, enemas, anti-diarrheal agents, narcotics, antacids,
antispasmodics, diuretics, anticonvulsants).
- High BMI that is not representative of being overweight or obese (e.g. resistance
trained individuals, football players)
- Prior malabsorptive bariatric surgery (i.e. gastric bypass, sleeve gastrectomy) or
restrictive bariatric surgery (i.e. adjustable gastric band) within the past 2 years
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