Effects of Tolcapone on Decision Making and Alcohol Intake in Alcohol Users

The study is a 7-session, double blind, placebo-controlled crossover study of the effects of
tolcapone, the COMT inhibitor, on decision making and alcohol intake using a laboratory bar
in moderate to heavy social alcohol drinkers. Subjects will be moderate to heavy social users
of alcohol, defined as at least 10 standard drinks per week for women and at least 14
standard drinks per week for men. There will be one screening session followed by six
additional visits including 2 laboratory bar sessions. On each study drug administration day,
subjects will come in to the clinic for a medication dispensation visit and instructions on
when and how to take the study drug for the remainder of the study. Study drug bottles will
be equipped with MEMS caps to ensure compliance. After 5 days of drug administration,
subjects will return to the clinic for a laboratory bar. This session will consist of
administration of a standardized laboratory bar paradigm and a series of computerized and
written decision-making tasks. Subjects will then be crossed over and complete the same
series of study visits on the alternate study drug.

Inclusion Criteria:

- Healthy volunteers who are 21-40 years of age

- If female, 10 or more alcoholic drinks must be consumed weekly.

- If male, 14 or more alcoholic drinks must be consumed weekly.

- Meets DSM-V criteria for Alcohol Use Disorder (AUD).

- If female, must be non-lactating, not pregnant, and using a reliable contraception
method (i.e. abstinence, intrauterine device [IUD], hormonal birth control, or barrier
method).

- Ability to read and speak English.

- High school graduate.

- Able and willing to provide an informed consent.

- Able to understand and follow the instructions of the investigator, including the
delayed discounting tasks. Residing within 5 miles of the study site.

Exclusion Criteria:

- Positive urine drug screen (except marijuana).

- Using cocaine, stimulants (other than nicotine and caffeine), amphetamines,
hallucinogens, ecstasy, opiates, sedatives, pain pills, sleeping pills. or other
psychoactive drugs within 2 weeks of the start of the study (except marijuana).

- Marijuana use more than 3 times/week.

- Current enrollment in an alcohol, or other drug treatment program or current legal
problems relating to alcohol, or other drug use.

- Currently trying to quit alcohol use.

- History of major alcohol related complications within the preceding 2 years (liver
failure/cirrhosis, pancreatitis, esophageal varices, etc.).

- Two SGPT/ALT or SGOT/AST values greater than the upper limit of normal.

- Unable to pass the Standard Field Sobriety Test in a sober state (BAC = 0.00).

- BAC level >0.05% at the beginning of screening visit (within margin of error of
detection).

- Regular use of any of the drugs on the tolcapone contraindications list OR within 2
weeks of drug administration.

- Severe low blood (< 90/50) pressure or uncontrolled high blood pressure (>160/100).
Allergy or intolerance to tolcapone.

- Subject has received an investigational drug within 30 days of the screening visit.

- Subject is considered unsuitable for the study in the opinion of the investigator or
clinician for any other reason (such as an Axis II personality disorder that makes the
subject unable to comply with study instructions, per the Clinician's judgement.)