Brain Sleep Deprivation MRI Effects (BEDTIME)
| Status: | Not yet recruiting |
|---|---|
| Conditions: | Alzheimer Disease, Insomnia Sleep Studies |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 21 - 30 |
| Updated: | 4/17/2018 |
| Start Date: | June 2018 |
| End Date: | December 2018 |
| Contact: | Ricardo Osorio Suarez, MD |
| Email: | Ricardo.Osorio@nyumc.org |
| Phone: | 212-263-3255 |
Open Masking, Micro Motionlogger Actigraph, 3T Siemens MRI, Sleep Deprivation, Nocturnal PSG
The primary purpose of this study is to explore the underlying mechanisms that link sleep to
Alzheimer's disease (AD), with special focus on the clearance of metabolites in the
extracellular space of the brain during sleep. Subjects will wear an actigraph for 1 week to
determine regular daytime activity and sleep patterns. Subjects will then undergo partial
sleep deprivation followed by 4 hours of in-lab nocturnal polysomnography (NPSG).
Participants will be be asked to stay awake and active all day after the partial sleep
deprivation with a new actigraphy secured by a hospital band to assure participants remain
awake. They will seep inside an MRI machine for 90 minutes on the following night during
their usual bedtime (established by 1 week actigraphy study.) Morphologic imaging, flow
imaging and diffusion kurtosis imaging (DKI) will be performed on a 3T Siemens scanner.
Alzheimer's disease (AD), with special focus on the clearance of metabolites in the
extracellular space of the brain during sleep. Subjects will wear an actigraph for 1 week to
determine regular daytime activity and sleep patterns. Subjects will then undergo partial
sleep deprivation followed by 4 hours of in-lab nocturnal polysomnography (NPSG).
Participants will be be asked to stay awake and active all day after the partial sleep
deprivation with a new actigraphy secured by a hospital band to assure participants remain
awake. They will seep inside an MRI machine for 90 minutes on the following night during
their usual bedtime (established by 1 week actigraphy study.) Morphologic imaging, flow
imaging and diffusion kurtosis imaging (DKI) will be performed on a 3T Siemens scanner.
Inclusion Criteria:
- Capable of giving informed consent
Exclusion Criteria:
- Diagnosis of any brain disease or brain damage including significant trauma,
hydrocephalus, seizures, mental retardation or other serious neurological disorders
(e.g. Parkinson's disease or other movement disorders). Persons with silent cortical
infarcts will be excluded. White matter lesions will not be exclusions.
- History of major psychiatric illness (e.g., schizophrenia, bipolar or life long
history of major depression)
- Conditions that alter normal sleep patterns: irregular sleep-wake rhythms (based on
one week at home monitoring with actigraphy), moderate to severe periodic limb
movement while you sleep (PLMS) or Obstructive Sleep Apnea (OSA).
- History of claustrophobia.
- BMI≥30
- Significant history of alcoholism or drug abuse.
- Inability to avoid the use of alcohol or caffeine during the 48h before the MRI.
- Current pregnancy or intent to become pregnant during the period of study.
- Any electronic or ferromagnetic devices (e.g., pacemaker or surgical clips) that
constitutes a hazard for MRI imaging.
- Any medications adversely affecting cognition, blood pressure, glucose metabolism, or
sleep will result in exclusion.
We found this trial at
1
site
550 1st Ave
New York, New York 10016
New York, New York 10016
(212) 263-7300
Principal Investigator: Ricardo Osorio Suarez, MD
New York University School of Medicine NYU School of Medicine has a proud history that...
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