PF-06671008 Dose Escalation Study in Advanced Solid Tumors
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/5/2019 |
| Start Date: | April 28, 2016 |
| End Date: | April 4, 2019 |
A PHASE 1 DOSE ESCALATION STUDY EVALUATING THE SAFETY AND TOLERABILITY OF PF-06671008 IN PATIENTS WITH ADVANCED SOLID TUMORS
The study will evaluate the safety, pharmacokinetics and pharmacodynamics of increasing doses
of PF-06671008 in patients with advanced solid tumors with the potential to have P-cadherin
expression. The study will then expand to look at the selected dose in patients with
P-cadherin expressing TNBC, CRC or NSCLC.
of PF-06671008 in patients with advanced solid tumors with the potential to have P-cadherin
expression. The study will then expand to look at the selected dose in patients with
P-cadherin expressing TNBC, CRC or NSCLC.
Key Inclusion Criteria
- Diagnosis of tumor type with the potential to have P-cadherin expression that is
resistant to standard therapy or for which no standard therapy is available
- Performance status of 0 or 1
- Adequate bone marrow, kidney and liver function
Key Exclusion Criteria
- Known CNS disease including, but not limited to, metastases
- Current or history of seizure disorder
- History of or active autoimmune disorders
- Active bacterial, fungal or viral infection
- Major surgery, anti-cancer therapy, or radiation therapy within 4 weeks of study
treatment
- Requirement for systemic immune suppressive medication
- Grade 2 or greater peripheral neuropathy
We found this trial at
8
sites
Click here to add this to my saved trials
Click here to add this to my saved trials
1515 Holcombe Blvd
Houston, Texas 77030
Houston, Texas 77030
713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials