PF-06671008 Dose Escalation Study in Advanced Solid Tumors
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/5/2019 |
| Start Date: | April 28, 2016 |
| End Date: | April 4, 2019 |
A PHASE 1 DOSE ESCALATION STUDY EVALUATING THE SAFETY AND TOLERABILITY OF PF-06671008 IN PATIENTS WITH ADVANCED SOLID TUMORS
The study will evaluate the safety, pharmacokinetics and pharmacodynamics of increasing doses
of PF-06671008 in patients with advanced solid tumors with the potential to have P-cadherin
expression. The study will then expand to look at the selected dose in patients with
P-cadherin expressing TNBC, CRC or NSCLC.
of PF-06671008 in patients with advanced solid tumors with the potential to have P-cadherin
expression. The study will then expand to look at the selected dose in patients with
P-cadherin expressing TNBC, CRC or NSCLC.
Key Inclusion Criteria
- Diagnosis of tumor type with the potential to have P-cadherin expression that is
resistant to standard therapy or for which no standard therapy is available
- Performance status of 0 or 1
- Adequate bone marrow, kidney and liver function
Key Exclusion Criteria
- Known CNS disease including, but not limited to, metastases
- Current or history of seizure disorder
- History of or active autoimmune disorders
- Active bacterial, fungal or viral infection
- Major surgery, anti-cancer therapy, or radiation therapy within 4 weeks of study
treatment
- Requirement for systemic immune suppressive medication
- Grade 2 or greater peripheral neuropathy
We found this trial at
8
sites
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1515 Holcombe Blvd
Houston, Texas 77030
Houston, Texas 77030
713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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