Non-Surgical Management of Attenuated and Deleterious (Classical) Familial Adenomatous Polyposis: A Long-term Surveillance Program

The UTMDACC family history database will be queried for the presence of cases meeting the
above criteria (attenuated Familial Adenomatous Polyposis (FAP), classical AFP [i.e.
identifiable APC mutation], and/or a compatible family history or personal adenoma burden of
> 50 adenomas).

The data related to the patients with attenuated FAP and classical AFP who underwent
endoscopic surveillance or surgery will be collected through chart review and all data is
retrospective as of February 15, 2016.

The University of Texas MD Anderson Cancer Center (UTMDACC) medical record number for these
cases will be used to identify the patient in ClinicStation: 1) records of endoscopy
procedures, 2) operative reports, and 3) associated clinic notes will be reviewed for: a)
whether the above evaluation criteria have been met, b) age, c) gender, d) age at initial
colonoscopy, e) total number of colonoscopies, f) number of adenomas identified, g) cancer
diagnoses, h) chemopreventive medications, i) type of surgery, j) number of hospitalizations,
k) length of hospital stay, l) identification of an underlying APC mutation, and ll) family
history information. The UT MDACC family history database will also be reviewed for updated
family history information including ampullary adenomas and outcomes of genetic testing for
identified cases.

Inclusion Criteria:

1. Participants with either a genetic diagnosis of AFAP/FAP (i.e. an identifiable APC gene
mutation), and/or a compatible family history and pathology including history of ampullary
adenoma in the duodenum over family generations, or personal adenoma burden of > 50
adenomas are to be included.

Exclusion Criteria:

1. Participants who do not have with Attenuated Familial Adenomatous Polyposis (AFAP) and
Deleterious Familial Adenomatous Polyposis (FAP).